Brain region-specific, age-related, alterations in mitochondrial responses to elevated calcium

Journal of Bioenergetics and Biomembranes
Maile R BrownPatrick G Sullivan

Abstract

An age-related Ca(2+) dysregulation and increased production of reactive oxygen species (ROS) may contribute to late-onset neurodegenerative disorders. These alterations are often attributed to impaired mitochondrial function yet few studies have directly examined mitochondria isolated from various regions of the aged brain. The purpose of this study was to examine Ca(2+)-buffering and ROS production in mitochondria isolated from Fischer 344 rats ranging in age from 4 to 25 months. Mitchondria isolated from the cortex of the 25 month rat brain exhibited greater rates of ROS production and mitochondrial swelling in response to increasing Ca(2+) loads as compared to mitochondria isolated from younger (4, 13 month) animals. The increased swelling is indicative of opening of the mitochondrial permeability transition pore indicating impaired Ca(2+) buffering/cycling in aged animals. These age-related differences were not observed in mitochondria isolated from cerebellum. Together, these results demonstrate region specific, age-related, alterations in mitochondrial responses to Ca(2+).

Citations

Feb 12, 2011·Journal of Bioenergetics and Biomembranes·Julia Toman, Gary Fiskum
Mar 23, 2006·Nature Reviews. Neuroscience·Mark P Mattson, Tim Magnus
Aug 19, 2007·Antioxidants & Redox Signaling·P Hemachandra Reddy
Feb 24, 2010·Journal of Neurotrauma·Lesley K GilmerStephen W Scheff
May 13, 2008·Investigative Ophthalmology & Visual Science·Won-Kyu JuRobert N Weinreb
Apr 30, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Eric M BlalockPhilip W Landfield
Dec 3, 2013·European Journal of Pharmacology·J C GantP W Landfield
Jan 15, 2011·Journal of Aging Research·Ricardo Gredilla
Apr 23, 2016·Neurobiology of Aging·Sathyanarayanan RajagopalSurojit Paul
May 26, 2009·Experimental Neurology·Janet M Dubinsky
Aug 5, 2008·Trends in Neurosciences·Ilya Bezprozvanny, Mark P Mattson
Dec 25, 2007·Annals of Neurology·Don M GashT Scott Prince
Nov 20, 2009·Journal of Neurochemistry·Mei LiuGuoying Bing
Sep 10, 2014·The Cerebellum·Marianna E Jung
Jan 26, 2010·Experimental Gerontology·Ricardo GredillaTinna Stevnsner
Aug 15, 2008·Neurobiology of Aging·Ricardo GredillaTinna Stevnsner
Dec 5, 2014·Journal of Bioenergetics and Biomembranes·Heather M YonutasPatrick G Sullivan
Jun 12, 2018·Aging Cell·Mathieu PanelDidier Morin
Sep 1, 2006·Developmental Neuroscience·Courtney L RobertsonGary Fiskum
Mar 7, 2006·The Journal of Biological Chemistry·Maile R BrownJames W Geddes
Apr 18, 2019·International Journal of Molecular Sciences·Jong Min KimHo Jin Heo
Aug 29, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Seung-Eon RohDavid E Kang
Jan 21, 2017·Oxidative Medicine and Cellular Longevity·Jin Yong KangHo Jin Heo
Jun 19, 2019·Oxidative Medicine and Cellular Longevity·Bong Seok KwonHo Jin Heo
Dec 15, 2020·Oxidative Medicine and Cellular Longevity·Jong Min KimHo Jin Heo
Feb 28, 2021·Ageing Research Reviews·Virenkumar A Pandya, Rickie Patani
Jun 7, 2018·Cell Metabolism·Mark P Mattson, Thiruma V Arumugam
Jun 14, 2021·Behavioral and Brain Functions : BBF·Aliabbas ZiaSaeed Samarghandian

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Respiration

This feed focuses on cellular respiration in bacteria, known as bacterial respiration. Discover the latest research here.