Brain region-specificity of palmitic acid-induced abnormalities associated with Alzheimer's disease.

BMC Research Notes
Sachin PatilChristina Chan

Abstract

Alzheimer's disease (AD) is a progressive, neurodegenerative disease mostly affecting the basal forebrain, cortex and hippocampus whereas the cerebellum is relatively spared. The reason behind this region-specific brain damage in AD is not well understood. Here, we report our data suggesting "differential free fatty acid metabolism in the different brain areas" as a potentially important factor in causing the region-specific damage observed in AD brain. The astroglia from two different rat brain regions, cortex (region affected in AD) and cerebellum (unaffected region), were treated with 0.2 mM of palmitic acid. The conditioned media were then transferred to the cortical neurons to study the possible effects on the two main, AD-associated protein abnormalities, viz. BACE1 upregulation and hyperphosphorylation of tau. The conditioned media from palmitic-acid treated cortical astroglia, but not the cerebellar astroglia, significantly elevated levels of phosphorylated tau and BACE1 in cortical neurons as compared to controls (47 +/- 7% and 45 +/- 4%, respectively). The present data provide an experimental explanation for the region-specific damage observed in AD brain; higher fatty acid-metabolizing capacity of cortical astroglia ...Continue Reading

References

Apr 1, 1993·Journal of Neurochemistry·L J ChandlerF Crews
Apr 27, 1996·Lancet·I SkoogA Svanborg
Jul 1, 1997·Journal of Neurochemistry·P HomayounN G Bazan
Jan 24, 1998·Toxicology and Applied Pharmacology·M S Marty, W D Atchison
May 1, 1999·The Journal of Biological Chemistry·C F BearerG Cheng
Oct 3, 1999·Physiological Reviews·P Lipton
Apr 4, 2000·Neurology·Z GuoL A Farrer
Oct 29, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C BlázquezM Guzmán
Sep 6, 2002·Journal of Alzheimer's Disease : JAD·W B Grant
Mar 21, 2003·Metabolism: Clinical and Experimental·Grace J PetotRobert P Friedland
May 19, 2004·Archives of Neurology·Zoe ArvanitakisDavid A Bennett
Aug 6, 2004·Nature·Mark P Mattson
May 3, 2005·BMJ : British Medical Journal·Rachel A WhitmerKristine Yaffe
Apr 28, 2006·Brain Research·Teresa Cunha-OliveiraCatarina R de Oliveira
Oct 3, 2007·The European Journal of Neuroscience·Sachin PatilChristina Chan

❮ Previous
Next ❯

Citations

Nov 22, 2012·Clinical and Experimental Pharmacology & Physiology·Ryusuke TakechiJohn C Mamo
Feb 8, 2011·Journal of Biomaterials Science. Polymer Edition·Sumit MehrotraChristina Chan
Nov 10, 2009·Progress in Lipid Research·R TakechiJ C L Mamo
Aug 1, 2014·Ageing Research Reviews·Evangelina Avila-Muñoz, Clorinda Arias
Sep 16, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vivitri PrasastyEnade Istyastono
Nov 14, 2019·International Journal of Molecular Sciences·Thomas Ho-Yin LeeSuk-Yu Yau

❮ Previous
Next ❯

Methods Mentioned

BETA
scraping
protein assay
FACS

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

Basal Forebrain & Food Avoidance

Neurons in the basal forebrain play specific roles in regulating feeding. Here are the latest discoveries pertaining to the basal forebrain and food avoidance.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.