Abstract
Alzheimer's disease (AD) is a progressive, neurodegenerative disease mostly affecting the basal forebrain, cortex and hippocampus whereas the cerebellum is relatively spared. The reason behind this region-specific brain damage in AD is not well understood. Here, we report our data suggesting "differential free fatty acid metabolism in the different brain areas" as a potentially important factor in causing the region-specific damage observed in AD brain. The astroglia from two different rat brain regions, cortex (region affected in AD) and cerebellum (unaffected region), were treated with 0.2 mM of palmitic acid. The conditioned media were then transferred to the cortical neurons to study the possible effects on the two main, AD-associated protein abnormalities, viz. BACE1 upregulation and hyperphosphorylation of tau. The conditioned media from palmitic-acid treated cortical astroglia, but not the cerebellar astroglia, significantly elevated levels of phosphorylated tau and BACE1 in cortical neurons as compared to controls (47 +/- 7% and 45 +/- 4%, respectively). The present data provide an experimental explanation for the region-specific damage observed in AD brain; higher fatty acid-metabolizing capacity of cortical astroglia ...Continue Reading
References
Oct 1, 1980·Journal of Neurochemistry·A Szutowicz, W Lysiak
Mar 17, 1995·The Journal of Biological Chemistry·S P Pshenichkin, B C Wise
Apr 1, 1993·Journal of Neurochemistry·L J ChandlerF Crews
Apr 27, 1996·Lancet·I SkoogA Svanborg
Jul 1, 1997·Journal of Neurochemistry·P HomayounN G Bazan
Jan 24, 1998·Toxicology and Applied Pharmacology·M S Marty, W D Atchison
May 1, 1999·The Journal of Biological Chemistry·C F BearerG Cheng
Oct 3, 1999·Physiological Reviews·P Lipton
Apr 4, 2000·Neurology·Z GuoL A Farrer
Jun 1, 2000·Nature·M S LeeL H Tsai
Oct 29, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C BlázquezM Guzmán
Sep 6, 2002·Journal of Alzheimer's Disease : JAD·W B Grant
Mar 21, 2003·Metabolism: Clinical and Experimental·Grace J PetotRobert P Friedland
Sep 17, 2003·The Journal of Biological Chemistry·Zhengtong PeiPaul A Watkins
May 4, 2004·Brain Research·Yi WenJames W Simpkins
May 19, 2004·Archives of Neurology·Zoe ArvanitakisDavid A Bennett
Aug 6, 2004·Nature·Mark P Mattson
May 3, 2005·BMJ : British Medical Journal·Rachel A WhitmerKristine Yaffe
Jun 9, 2005·Neuroscience Letters·Sachin Patil, Christina Chan
Apr 28, 2006·Brain Research·Teresa Cunha-OliveiraCatarina R de Oliveira
Jun 13, 2006·Neurobiology of Disease·M OksmanH Tanila
Aug 15, 2006·Neuroscience Letters·Sachin PatilChristina Chan
Oct 3, 2007·The European Journal of Neuroscience·Sachin PatilChristina Chan
Citations
Oct 29, 2009·The British Journal of Nutrition·Ryusuke TakechiJohn C L Mamo
Nov 22, 2012·Clinical and Experimental Pharmacology & Physiology·Ryusuke TakechiJohn C Mamo
Feb 8, 2011·Journal of Biomaterials Science. Polymer Edition·Sumit MehrotraChristina Chan
Nov 28, 2015·Analytical Chemistry·Lulu HuangHongying Zhong
Nov 8, 2011·Neurotoxicology and Teratology·Steve FordahlKeith M Erikson
Nov 10, 2009·Progress in Lipid Research·R TakechiJ C L Mamo
Sep 23, 2011·Brain Research·Juhae KimYoung Hye Kwon
Jan 16, 2013·Stem Cell Research·Qiuhuan YuanAijun Hao
Aug 1, 2014·Ageing Research Reviews·Evangelina Avila-Muñoz, Clorinda Arias
Sep 16, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vivitri PrasastyEnade Istyastono
Aug 30, 2020·BMC Plant Biology·Xiaoyi LiuPiwu Wang
Dec 20, 2018·Frontiers in Neuroscience·Joseph O OjoFiona Crawford
Nov 14, 2019·International Journal of Molecular Sciences·Thomas Ho-Yin LeeSuk-Yu Yau