Brain regional synchronous activity predicts tauopathy in 3×TgAD mice

Neurobiology of Aging
Dong LiuMark P Mattson

Abstract

Alzheimer's disease (AD) is characterized by progressive cognitive impairment and by extensive neuronal loss associated with extracellular amyloid β-peptide (Aβ) plaques and intraneuronal tau pathology in temporal and parietal lobes. AD patients are at increased risk for epileptic seizures, and data from experimental models of AD suggest that aberrant neuronal network activity occurs early in the disease process before cognitive deficits and neuronal degeneration. The contributions of Aβ and/or tau pathologies to dysregulation of neuronal network activity are unclear. Using a transgenic mouse model of AD (3×TgAD mice) in which there occurs differential age-dependent development of tau and Aβ plaque pathologies, we applied analysis of resting state functional magnetic resonance imaging regional homogeneity, a measure of local synchronous activity, to discriminate the effects of Aβ and tau on neuronal network activity throughout the brain. Compared to age-matched wild-type mice, 6- to 8-month-old 3×TgAD mice exhibited increased regional homogeneity in the hippocampus and parietal and temporal cortices, regions with tau pathology but not Aβ pathology at this age. By 18-24 months of age, 3×TgAD mice exhibited extensive tau and Aβ p...Continue Reading

Citations

Jun 4, 2019·International Journal of Molecular Sciences·Lorenzo Carnevale, Giuseppe Lembo
Nov 30, 2019·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Dimitri HefterMartin Korte
Oct 28, 2019·Nature Communications·Theresa M HarrisonWilliam J Jagust
May 30, 2020·Cellular and Molecular Life Sciences : CMLS·Caroline FischerIrmgard Tegeder
Nov 27, 2018·Journal of Alzheimer's Disease : JAD·Tauqeerunnisa SyedaClaudia Perez-Cruz
Nov 19, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Dong LiuMark P Mattson
Nov 14, 2020·Brain : a Journal of Neurology·Laetitia DegiorgisLaura-Adela Harsan

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