Brain regions with abnormal network properties in severe epilepsy of Lennox-Gastaut phenotype: Multivariate analysis of task-free fMRI

Epilepsia
Mangor PedersenGraeme D Jackson

Abstract

Lennox-Gastaut syndrome, and the similar but less tightly defined Lennox-Gastaut phenotype, describe patients with severe epilepsy, generalized epileptic discharges, and variable intellectual disability. Our previous functional neuroimaging studies suggest that abnormal diffuse association network activity underlies the epileptic discharges of this clinical phenotype. Herein we use a data-driven multivariate approach to determine the spatial changes in local and global networks of patients with severe epilepsy of the Lennox-Gastaut phenotype. We studied 9 adult patients and 14 controls. In 20 min of task-free blood oxygen level-dependent functional magnetic resonance imaging data, two metrics of functional connectivity were studied: Regional homogeneity or local connectivity, a measure of concordance between each voxel to a focal cluster of adjacent voxels; and eigenvector centrality, a global connectivity estimate designed to detect important neural hubs. Multivariate pattern analysis of these data in a machine-learning framework was used to identify spatial features that classified disease subjects. Multivariate pattern analysis was 95.7% accurate in classifying subjects for both local and global connectivity measures (22/23 ...Continue Reading

References

Jan 1, 1993·Epilepsia·O Dulac, T N'Guyen
Mar 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K J FristonR Turner
Aug 25, 2001·Epilepsia·O Dulac
Apr 28, 2004·NeuroImage·Yufeng ZangLixia Tian
Nov 2, 2004·Neural Computation·David R HardoonJohn Shawe-Taylor
Aug 11, 2006·Trends in Cognitive Sciences·Kenneth A NormanJames V Haxby
Apr 11, 2008·Annals of the New York Academy of Sciences·Randy L BucknerDaniel L Schacter
Sep 10, 2008·Neurology·Sheryl R Haut, Roger L Albin
Dec 17, 2008·NeuroImage·Francisco PereiraMatthew Botvinick
Feb 5, 2009·Nature Reviews. Neuroscience·Ed Bullmore, Olaf Sporns
Apr 22, 2010·Frontiers in Systems Neuroscience·David M ColeChristian F Beckmann
Jun 1, 2010·Brain Structure & Function·Vinod Menon, Lucina Q Uddin
Jun 26, 2010·Frontiers in Systems Neuroscience·Yan Chao-Gan, Zang Yu-Feng
Aug 4, 2011·NeuroImage·Koene R A Van DijkRandy L Buckner
Oct 5, 2011·Cerebral Cortex·Xi-Nian ZuoMichael P Milham
Nov 19, 2011·NeuroImage·Stefan KlöppelPrashanthi Vemuri
Feb 7, 2012·Neuroscience and Biobehavioral Reviews·Graziella OrrùAndrea Mechelli
Nov 9, 2012·Nature·Ben Deen, Kevin Pelphrey
Feb 19, 2013·Neuroinformatics·J SchrouffJ Mourão-Miranda
Jun 7, 2014·Epilepsia·John S ArcherGraeme D Jackson
Nov 18, 2014·Frontiers in Neurology·John S ArcherDavid F Abbott

❮ Previous
Next ❯

Citations

Nov 6, 2015·Brain Connectivity·Mangor PedersenGraeme Jackson
Feb 13, 2019·Psychological Medicine·Adrian B R ShatteSamantha J Teague
Nov 29, 2016·Frontiers in Neuroscience·José M SoaresNuno Sousa
Jun 7, 2017·Journal of Neurology·Sophie DupontVi-Huong Nguyen-Michel
Jul 10, 2021·Frontiers in Neuroscience·Daichi Sone, Iman Beheshti

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.