PMID: 6159649Sep 1, 1980Paper

Brain regulation of gastric secretion: influence of neuropeptides

Proceedings of the National Academy of Sciences of the United States of America
Y TachéM Brown

Abstract

Several neuropeptides injected intracisternally were assessed for their effects on gastric secretion in rats. Bombesin (1 microgram) completely suppressed gastric acid secretion, produced the volume of gastric secretion, and partially blocked insulin- or 2-deoxy-D-glucose-induced stimulation of gastric acid output. The inhibitory effect of this peptide is dose-dependent, long-acting, reversible, and specific. Bombesin response appears to be central nervous system-mediated; its expression is not dependent on the vagus nerve or the adrenal glands, and does not rely on a decrease in gastrin secretion. Among seven other peptides tested, only beta-endorphin and a potent gonadotropin releasing-factor (gonadoliberin) agonist significantly reduced gastric acid secretion, with an activity ca. 100 times less than that of bombesin. The presence of bombesin-like material in rat brain and the high potency of bombesin to inhibit gastric secretion suggest that this peptide may be of physiologic significance as a chemical messenger involved in brain modulation of gastric secretion.

References

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Jan 1, 1979·Annual Review of Physiology·A H Soll, J H Walsh
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Citations

Aug 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·T NakadateR Kato
Jan 1, 1983·Digestive Diseases and Sciences·Y Goto, H T Debas
Dec 1, 1989·Digestive Diseases and Sciences·D E Hernandez
Dec 14, 1981·Brain Research·A S LevineS E Silvis
Oct 26, 1981·Brain Research·T YamadaR H Gerner
Dec 1, 1987·Developmental Biology·I ZacharyE Rozengurt
Oct 22, 1982·European Journal of Pharmacology·D E HernandezA J Prange
May 20, 1983·European Journal of Pharmacology·M Maeda-Hagiwara, K Watanabe
Aug 15, 1985·European Journal of Pharmacology·D E GmerekA Cowan
Oct 13, 1994·European Journal of Pharmacology·L S JonesL H Lazarus
Aug 2, 1982·Life Sciences·J E MorleyS E Silvis
Aug 16, 1982·Life Sciences·J E MorleyS E Silvis
May 23, 1983·Life Sciences·F E Rasler
Jan 1, 1988·Life Sciences·T F BurksF Porreca
Apr 1, 1985·Pharmacology, Biochemistry, and Behavior·D E HernandezA J Prange
May 1, 1983·Peptides·D E NiewoehnerJ E Morley
Jan 1, 1985·Peptides·J E MorleyS E Nizielski

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