Brain response to food stimulation in obese, normal weight, and successful weight loss maintainers.

Obesity
Lawrence SweetRena R Wing

Abstract

As many people struggle with maintenance of weight loss, the study of successful weight loss maintainers (SWLM) can yield important insights into factors contributing to weight loss maintenance. However, little research has examined how SWLM differ from people who are obese or normal weight (NW) in brain response to orosensory stimulation. The goal of this study was to determine if SWLM exhibit different brain responses to orosensory stimulation. Brain response to 1-min orosensory stimulation with a lemon lollipop was assessed using functional magnetic resonance imaging among 49 participants, including SWLM (n = 17), NW (n = 18), and obese (n = 14) controls. Significant brain responses were observed in nine brain regions, including the bilateral insula, left inferior frontal gyrus, left putamen, and other sensory regions. All regions also exhibited significant attenuation of this response over 1 min. The SWLM exhibited greater response compared with the other groups in all brain regions. Findings suggest that the response to orosensory stimulation peaks within 40 s and attenuates significantly between 40 and 60 s in regions associated with sensation, reward, and inhibitory control. Greater reactivity among the SWLM suggests tha...Continue Reading

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Citations

Jan 23, 2016·Frontiers in Behavioral Neuroscience·David MatharJane Neumann
Feb 20, 2016·Obesity·Nancy PuzziferriCarol A Tamminga
Dec 8, 2015·Frontiers in Psychology·Anita JansenAnne Roefs
Jan 24, 2015·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·H MünzbergH-R Berthoud
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Jan 15, 2013·Physiology & Behavior·Marc-Andre CornierJason R Tregellas
Jan 23, 2016·The European Journal of Neuroscience·Hazel WrightAndrej Stancak
Jan 19, 2017·Current Opinion in Endocrinology, Diabetes, and Obesity·Laura PatriarcaMiguel Alonso-Alonso
Mar 10, 2017·Current Opinion in Endocrinology, Diabetes, and Obesity·Laura PatriarcaMiguel Alonso-Alonso
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Aug 2, 2017·Current Obesity Reports·Luzia Jaeger HintzeÉric Doucet
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Jan 14, 2020·Brain Imaging and Behavior·Marie ArsalidouMaksim Sharaev
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Software Mentioned

FMRI
Statistical Package for the Social Sciences ( SPSS
Analysis of Functional NeuroImages AFNI )
Prime

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