Brain responses to chronic social defeat stress: effects on regional oxidative metabolism as a function of a hedonic trait, and gene expression in susceptible and resilient rats

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
Margus KanarikJaanus Harro

Abstract

Chronic social defeat stress, a depression model in rats, reduced struggling in the forced swimming test dependent on a hedonic trait-stressed rats with high sucrose intake struggled less. Social defeat reduced brain regional energy metabolism, and this effect was also more pronounced in rats with high sucrose intake. A number of changes in gene expression were identified after social defeat stress, most notably the down-regulation of Gsk3b and Map1b. The majority of differences were between stress-susceptible and resilient rats. Conclusively, correlates of inter-individual differences in stress resilience can be identified both at gene expression and oxidative metabolism levels.

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Citations

Feb 22, 2012·European Archives of Psychiatry and Clinical Neuroscience·Daniel Martins-de-SouzaSabine Bahn
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Dec 19, 2018·Cell and Tissue Research·Jaanus Harro
Jul 23, 2019·Progress in Neuro-psychopharmacology & Biological Psychiatry·Chelsea R McCoySarah M Clinton

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