Brain responses to different types of salience in antipsychotic naïve first episode psychosis: An fMRI study.

Translational Psychiatry
Franziska KnolleGraham K Murray

Abstract

Abnormal salience processing has been suggested to contribute to the formation of positive psychotic symptoms in schizophrenia and related conditions. Previous research utilising reward learning or anticipation paradigms has demonstrated cortical and subcortical abnormalities in people with psychosis, specifically in the prefrontal cortex, the dopaminergic midbrain and the striatum. In these paradigms, reward prediction errors attribute motivational salience to stimuli. However, little is known about possible abnormalities across different forms of salience processing in psychosis patients, and whether any such abnormalities involve the dopaminergic midbrain. The aim of our study was, therefore, to investigate possible alterations in psychosis in neural activity in response to various forms of salience: novelty, negative emotion, targetness (task-driven salience) and rareness/deviance. We studied 14 antipsychotic naïve participants with first episode psychosis, and 37 healthy volunteers. During fMRI scanning, participants performed a visual oddball task containing these four forms of salience. Psychosis patients showed abnormally reduced signalling in the substantia nigra/ventral tegmental area (SN/VTA) for novelty, negative em...Continue Reading

References

Jan 1, 1987·Schizophrenia Bulletin·S R KayL A Opler
May 1, 1995·Psychosomatics·R C Hall
Jul 11, 1998·Journal of Neurophysiology·W Schultz
Dec 18, 2001·Human Brain Mapping·Thomas E Nichols, Andrew P Holmes
Oct 10, 2002·Neural Networks : the Official Journal of the International Neural Network Society·Sham Kakade, Peter Dayan
Mar 4, 2003·Nature Reviews. Neuroscience·Charan Ranganath, Gregor Rainer
Nov 16, 2004·Trends in Neurosciences·Mark A Ungless
Feb 4, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Stephan F TaylorIsrael Liberzon
Aug 2, 2006·Neuron·Nico Bunzeck, Emrah Düzel
Aug 25, 2006·Nature·Mathias PessiglioneChris D Frith
Mar 27, 2007·Cerebral Cortex·Nico BunzeckEmrah Düzel
Aug 11, 2007·Brain : a Journal of Neurology·P R CorlettP C Fletcher
Oct 19, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniel J Lodge, Anthony A Grace
Jan 19, 2008·The British Journal of Psychiatry. Supplement·Stefan J BorgwardtAnita Riecher-Rössler
Dec 18, 2007·Molecular Psychiatry·E S GershonJ A Badner
Jun 14, 2008·Biological Psychiatry·Pamela D ButlerSteven C Dakin
Aug 13, 2008·Psychological Medicine·J Jensen, S Kapur
Jan 7, 2009·Archives of General Psychiatry·Oliver D HowesPaul M Grasby
Jun 19, 2010·Progress in Neurobiology·P R CorlettJ H Krystal
Dec 15, 2010·Neuron·Ethan S Bromberg-MartinOkihide Hikosaka
Apr 13, 2011·Brain : a Journal of Neurology·Victoria B GradinJ Douglas Steele
Jun 23, 2011·Journal of Psychiatry & Neuroscience : JPN·Lena Palaniyappan, Peter F Liddle
Jul 28, 2011·European Archives of Psychiatry and Clinical Neuroscience·Evelina HaralanovaKristina Hennig-Fast
Jun 2, 2012·Frontiers in Human Neuroscience·Daniel H Mathalon, Judith M Ford
Sep 6, 2012·Schizophrenia Bulletin·Gauri N SavlaElizabeth W Twamley
Nov 14, 2012·Psychiatry Research·Victoria B GradinJ Douglas Steele
Dec 14, 2012·Schizophrenia Bulletin·Jonathan P RoiserPhilip McGuire
Jan 12, 2013·Cerebral Cortex·Nico BunzeckEmrah Duzel
Mar 15, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christopher D FiorilloMinryung R Song
Jun 5, 2013·The American Journal of Psychiatry·Javier BernacerGraham K Murray
Oct 30, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jennifer A HadleyAdrienne C Lahti
Dec 3, 2013·NeuroImage·Florian SchlagenhaufAndreas Heinz
Jan 7, 2014·Trends in Neurosciences·Toby T Winton-BrownOliver D Howes
Feb 18, 2014·NeuroImage·Anderson M WinklerThomas E Nichols
Feb 3, 2016·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Oliver D Howes, Matthew M Nour

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