Brain responses to high-protein diets.

Advances in Nutrition
Marion JournelDaniel Tomé

Abstract

Proteins are suspected to have a greater satiating effect than the other 2 macronutrients. After protein consumption, peptide hormones released from the gastrointestinal tract (mainly anorexigenic gut peptides such as cholecystokinin, glucagon peptide 1, and peptide YY) communicate information about the energy status to the brain. These hormones and vagal afferents control food intake by acting on brain regions involved in energy homeostasis such as the brainstem and the hypothalamus. In fact, a high-protein diet leads to greater activation than a normal-protein diet in the nucleus tractus solitarius and in the arcuate nucleus. More specifically, neural mechanisms triggered particularly by leucine consumption involve 2 cellular energy sensors: the mammalian target of rapamycin and AMP-activated protein kinase. In addition, reward and motivation aspects of eating behavior, controlled mainly by neurons present in limbic regions, play an important role in the reduced hedonic response of a high-protein diet. This review examines how metabolic signals emanating from the gastrointestinal tract after protein ingestion target the brain to control feeding, energy expenditure, and hormones. Understanding the functional roles of brain are...Continue Reading

References

May 1, 1989·The Journal of Nutrition·A E Harper, J C Peters
Jan 1, 1987·Physiology & Behavior·B A SemonD W Gietzen
Sep 1, 1997·Physiology & Behavior·M PorriniJ E Blundell
Sep 25, 1998·Physiology & Behavior·S D PoppittR Buffenstein
Jun 22, 1999·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·A R SkovA Astrup
Jul 14, 1999·European Journal of Clinical Nutrition·M S Westerterp-PlantengaK R Westerterp
Jan 29, 2000·Nature Neuroscience·N ChaudhariS D Roper
Feb 24, 2001·The Journal of Nutrition·C JeanD Tomé
Mar 15, 2002·Nature·Greg NelsonCharles S Zuker
Jun 14, 2002·Physiology & Behavior·Ahmed BensaïdGilles Fromentin
Feb 11, 2003·Physiology & Behavior·Ahmed BensaïdGilles Fromentin
Nov 26, 2003·Cell·Grace Q ZhaoCharles S Zuker
Jan 8, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M S Westerterp-PlantengaE M R Kovacs
Jun 3, 2004·The Journal of Nutrition·Diane L'Heureux-BouronGilles Fromentin
Feb 19, 2005·Endocrinology·Shuichi KodaMasamitsu Nakazato
Jun 3, 2005·The Journal of Nutrition·N P DarcelH E Raybould
Jul 5, 2005·NeuroImage·Laura M HolsenCary R Savage
Aug 12, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Natsuko TsujinoTakeshi Sakurai
Sep 27, 2005·Biochemical and Biophysical Research Communications·Kimio MatsumuraSusumu Seino
May 13, 2006·Science·Daniela CotaRandy J Seeley
Sep 5, 2006·Cell Metabolism·Rachel L BatterhamDominic J Withers
Feb 10, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sungwon ChoiGregory W Aponte
Mar 22, 2007·American Journal of Physiology. Endocrinology and Metabolism·Christopher D MorrisonRoy J Martin
May 22, 2007·Physiology & Behavior·Kimberly P KinzigTimothy H Moran
May 22, 2007·The Journal of Nutrition·John D Fernstrom, Madelyn H Fernstrom
Feb 20, 2008·Physiology & Behavior·M VeldhorstM Westerterp-Plantenga
May 22, 2008·The Journal of Nutrition·Rodolphe FaipouxGilles Fromentin
Jan 30, 2009·The American Journal of Clinical Nutrition·Ananda Hochstenbach-WaelenKlaas R Westerterp
Apr 23, 2009·Physiology & Behavior·Margriet A B VeldhorstMargriet S Westerterp-Plantenga

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Citations

May 3, 2013·European Journal of Clinical Nutrition·O DavidenkoD Tomé
Sep 6, 2014·Journal of Nutritional Science·Lucile J M MartinHenri J W Dumon
Jul 19, 2014·Meat Science·Shalene H McNeill
Jun 1, 2016·International Journal of Pediatric Otorhinolaryngology·Terez Boshra KamelRasha K Ahmed
Oct 16, 2015·Scientific Reports·Yingying ZhuGuanghong Zhou
May 12, 2015·Obesity·James S Kinsey-JonesKevin G Murphy
Aug 20, 2015·The British Journal of Nutrition·Catherine ChaumontetDaniel Tomé
Mar 18, 2015·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Jessay G DevassyHarold M Aukema
May 6, 2016·Annual Review of Biochemistry·George A Soultoukis, Linda Partridge
Jul 20, 2016·Annual Review of Nutrition·Alicia L CarreiroRichard D Mattes
Sep 5, 2017·Nutrients·Shanon L Casperson, James N Roemmich
Jun 8, 2018·The Journal of Nutrition·Catherine ChaumontetDaniel Tomé
Mar 19, 2014·The Journal of Endocrinology·T TakahashiK Katoh
Feb 26, 2019·Endocrinology·Karlton R LarsonKaren K Ryan
Dec 12, 2012·Current Opinion in Clinical Nutrition and Metabolic Care·Tracy G Anthony, Dorothy W Gietzen
Dec 7, 2013·Current Opinion in Clinical Nutrition and Metabolic Care·Eveline A P Martens, Margriet S Westerterp-Plantenga
May 23, 2014·The American Journal of Clinical Nutrition·Sanne Griffioen-RooseCees de Graaf
May 17, 2015·Advances in Nutrition·Marta Cuenca-SánchezEsteban Orenes-Piñero
Oct 23, 2019·Annual Review of Physiology·Christi M GendronScott D Pletcher
Jan 1, 2017·Topoi : an International Review of Philosophy·Roberta Locatelli, Keith A Wilson
May 16, 2018·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·K L StanhopeR M Krauss
Jul 21, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lixin WangYvette Taché
Aug 22, 2018·Frontiers in Endocrinology·Mathijs DrummenMargriet Westerterp-Plantenga
Mar 31, 2019·International Journal of Molecular Sciences·Ewa ŻebrowskaAdrian Chabowski
Oct 25, 2020·Nutrients·Tien S DongJonathan P Jacobs
Mar 25, 2019·Physiology & Behavior·Daniel ToméDalila Azzout-Marniche
Oct 15, 2020·The Proceedings of the Nutrition Society·Daniel ToméDalila Azzout-Marniche
Nov 16, 2019·Journal of Agricultural and Food Chemistry·Daniel ToméDalila Azzout-Marniche

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