Brain responses to sound intensity changes dissociate depressed participants and healthy controls

Biological Psychology
Elisa M Ruohonen, Piia Astikainen

Abstract

Depression is associated with bias in emotional information processing, but less is known about the processing of neutral sensory stimuli. Of particular interest is processing of sound intensity which is suggested to indicate central serotonergic function. We tested weather event-related brain potentials (ERPs) to occasional changes in sound intensity can dissociate first-episode depressed, recurrent depressed and healthy control participants. The first-episode depressed showed larger N1 amplitude to deviant sounds compared to recurrent depression group and control participants. In addition, both depression groups, but not the control group, showed larger N1 amplitude to deviant than standard sounds. Whether these manifestations of sensory over-excitability in depression are directly related to the serotonergic neurotransmission requires further research. The method based on ERPs to sound intensity change is fast and low-cost way to objectively measure brain activation and holds promise as a future diagnostic tool.

Citations

Aug 11, 2019·Neuroscience and Biobehavioral Reviews·Fernando Soares de Aguiar Neto, João Luís Garcia Rosa
Aug 31, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Yi-Jhan TsengChia-Hsiung Cheng

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