Brain reward deficits accompany naloxone-precipitated withdrawal from acute opioid dependence

Pharmacology, Biochemistry, and Behavior
Jian Liu, Gery Schulteis

Abstract

Single injections with morphine can induce a state of acute opioid dependence in humans and animals, typically measured as precipitated withdrawal when an antagonist such as naloxone is administered 4-24 h after morphine. Repeated treatment with morphine results in a progressive shift in potency of naloxone to produce such acute withdrawal signs. The current study examined alterations in brain reward thresholds after acute and repeated treatment with morphine (5.6 mg/kg) using a discrete-trial current-intensity brain-stimulation reward procedure. Rats with stimulation electrodes aimed at the medial forebrain bundle at the level of the lateral hypothalamus were tested in twice daily sessions separated by 4 h. Separate groups of rats received treatment with morphine immediately after the first daily test session, and one of several doses of naloxone (0.10, 0.33, 1.0 mg/kg) 4 h later and immediately before the second session; these morphine and naloxone treatments were repeated for four consecutive days (Morphine-Repeat NAL). Additional groups examined the independent contribution of repeated morphine or repeated naloxone. One control group (Morphine-Vehicle) received morphine on all four treatment days, but vehicle before the sec...Continue Reading

Citations

Feb 8, 2005·Psychopharmacology·Andrew C Harris, Jonathan C Gewirtz
Jan 11, 2007·Psychopharmacology·Adrie W BruijnzeelMark S Gold
Aug 13, 2011·Psychopharmacology·Patrick E RothwellJonathan C Gewirtz
Aug 8, 2012·Psychopharmacology·Andrew C HarrisDavid Shelley
Apr 24, 2013·Psychopharmacology·Ewa GalajRobert Ranaldi
Jun 12, 2013·Neuropharmacology·George F KoobOlivier George
Jun 6, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Patrick E RothwellJonathan C Gewirtz
Jun 25, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Angelo BlasioPietro Cottone
Feb 17, 2006·Journal of Psychoactive Drugs·John J ColemanRobert L DuPont
Mar 1, 2011·The Journal of Pain : Official Journal of the American Pain Society·Louis P Vera-PortocarreroFrank Porreca
Jan 1, 2008·Drug Discovery Today. Disease Models·George F Koob
Mar 1, 2008·Pharmacology, Biochemistry, and Behavior·Zhongqi Zhang, Gery Schulteis
Aug 27, 2005·Pharmacology, Biochemistry, and Behavior·Gery SchulteisSally Tzeng
Jul 26, 2005·Peptides·Richard J Bodnar, Gad E Klein
Feb 6, 2014·Biological Psychiatry·Rachel J DonahueWilliam A Carlezon
Jan 15, 2015·European Journal of Pharmacology·George F Koob
Dec 7, 2014·Drug and Alcohol Dependence·Thomas F GamageAron H Lichtman
Nov 17, 2007·Nature Protocols·William A Carlezon, Elena H Chartoff
Jul 1, 2017·Epidemiology and Psychiatric Sciences·A M Prina
Sep 16, 2019·Biological Psychiatry·Lola WelschBrigitte Lina Kieffer

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