Brain serotonin critically contributes to the biological effects of electroconvulsive seizures

European Archives of Psychiatry and Clinical Neuroscience
Golo KronenbergFriederike Klempin

Abstract

Compounds targeting serotonin (5-HT) are widely used as antidepressants. However, the role of 5-HT in mediating the effects of electroconvulsive seizure (ECS) therapy remains undefined. Using Tph2-/- mice depleted of brain 5-HT, we studied the effects of ECS on behavior and neurobiology. ECS significantly prolonged the start latency in the elevated O-Maze test, an effect that was abolished in Tph2-/- mice. Furthermore, in the absence of 5-HT, the ECS-induced increase in adult neurogenesis and in brain-derived neurotrophic factor signaling in the hippocampus were significantly reduced. Our results indicate that brain 5-HT critically contributes to the neurobiological responses to ECS.

References

Mar 19, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·C Anthony AltarMichael G Palfreyman
Jan 13, 2005·Neuroscience Letters·M ZuegerP Gass
Jun 10, 2008·Behavioural Brain Research·Sabine ChourbajiPeter Gass
Jun 13, 2009·Proceedings of the National Academy of Sciences of the United States of America·Natalia AleninaMichael Bader
Jan 11, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Sinead O'DonovanDeclan M McLoughlin
Jul 27, 2012·Translational Psychiatry·V MosienkoN Alenina
May 10, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Friederike KlempinNatalia Alenina
Jun 27, 2014·Neural Plasticity·Peter RotheneichnerSebastien Couillard-Despres
Dec 23, 2017·BMC Biology·Sarah V BiedermannJohannes Fuss

❮ Previous
Next ❯

Citations

Jun 11, 2021·Frontiers in Cell and Developmental Biology·Andrei TurkinFriederike Klempin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved