Brain SERT Expression of Male Rats Is Reduced by Aging and Increased by Testosterone Restitution

Neuroscience Journal
José Jaime Herrera-PérezLucía Martínez-Mota

Abstract

In preclinical and clinical studies aging has been associated with a deteriorated response to antidepressant treatment. We hypothesize that such impairment is explained by an age-related decrease in brain serotonin transporter (SERT) expression associated with low testosterone (T) levels. The objectives of this study were to establish (1) if brain SERT expression is reduced by aging and (2) if the SERT expression in middle-aged rats is increased by T-restitution. Intact young rats (3-5 months) and gonad-intact middle-aged rats with or without T-restitution were used. The identification of the brain SERT expression was done by immunofluorescence in prefrontal cortex, lateral septum, hippocampus, and raphe nuclei. An age-dependent reduction of SERT expression was observed in all brain regions examined, while T-restitution recovered the SERT expression only in the dorsal raphe of middle-aged rats. This last action seems relevant since dorsal raphe plays an important role in the antidepressant action of selective serotonin reuptake inhibitors. All data suggest that this mechanism accounts for the T-replacement usefulness to improve the response to antidepressants in the aged population.

References

Dec 19, 1988·Neuroscience Letters·M G van LuijtelaarJ A Tonnaer
Nov 12, 1993·Neuroscience Letters·M FujitaM Tohyama
Jul 21, 1998·Journal of Affective Disorders·S N Seidman, J G Rabkin
Jan 8, 1999·Brain Research. Molecular Brain Research·J K McQueenG Fink
Sep 9, 1999·Psychiatric Services : a Journal of the American Psychiatric Association·C F Reynolds, D J Kupfer
Sep 24, 1999·Nature Neuroscience·H A Cameron, R D McKay
Oct 12, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·B G PollockD J Kupfer
May 16, 2002·Neurobiology of Aging·Julie A Markham, Janice M Juraska
Jun 21, 2002·Life Sciences·Masahiro YamamotoShuji Tanada
Dec 31, 2002·The American Journal of Psychiatry·Harrison G PopeJames I Hudson
Aug 7, 2004·Brain Research. Brain Research Reviews·Teige P SheehanDavid S Russell
Aug 11, 2004·Pharmacology, Biochemistry, and Behavior·Lucía Martínez-Mota, Alonso Fernández-Guasti
Sep 25, 2004·Hippocampus·J A MarkhamJ M Juraska
Jan 5, 2006·The American Journal of Psychiatry·Etienne Sibille, David A Lewis
Feb 17, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Magdalena N JayatissaOve Wiborg
Sep 14, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Christopher Pittenger, Ronald S Duman
Oct 5, 2007·Pharmacology, Biochemistry, and Behavior·Lucía Martínez-MotaAlonso Fernández-Guasti
Aug 30, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·J J Herrera-PérezA Fernández-Guasti
Feb 4, 2010·European Journal of Pharmacology·José Jaime Herrera-PérezAlonso Fernández-Guasti
Jan 17, 2012·The Journal of Clinical Psychiatry·Enrico TedeschiniGeorge I Papakostas
Mar 1, 2012·Hormones and Behavior·José Jaime Herrera-PérezAlonso Fernández-Guasti

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Citations

Mar 7, 2014·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Marina IvančićCynthia R Smith

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