PMID: 9442354Jan 27, 1998Paper

Brain sexual differentiation and gonadotropins secretion in the rat

Cellular and Molecular Neurobiology
D Becú-VillalobosC Libertun

Abstract

1. The present work deals with sexual differences in gonadotropin regulation in the rat and the role of sexual organization of the hypothalamus in determining such differences. 2. Sex differences between male and female rats, with regard to their control of gonadotropin secretion, go beyond whether or not gonadotropins are released cyclically. Rats show additional sex differences (a) in the response of gonadotropins to removal and imposition of negative feedback signals and (b) in the ontogeny of gonadotropin regulation from birth to puberty. 3. There is a sensitive developmental period during which sexual differentiation of neural substrates proceeds irreversibly under the influence of gonadal hormones. In the rat this period starts a few days before birth and ends approximately 10 days after birth. Female rats treated during this sensitive period with androgens or estrogens will permanently lose the capacity to release GnRH in response to estrogenic stimulation. 4. Nevertheless although sexual differentiation is dramatically affected by events during the neonatal period, recent data question the "critical" nature of this period, as it has been shown that testosterone can still act on neural substrates well beyond (15 to 30 da...Continue Reading

Citations

Apr 28, 2005·Experimental Biology and Medicine·Shabrine S Daftary, Andrea C Gore
Dec 1, 2007·Basic & Clinical Pharmacology & Toxicology·Zhaoping LiuWeixing Yan
Feb 19, 2008·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Christine M TenkKlaus-Peter Ossenkopp
Jul 19, 2013·Journal of Neurotrauma·Tiffany GrecoMayumi Prins
Jun 2, 2006·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·H NishioT Hirai
Mar 15, 2006·Biology of the Neonate·Carrie CannonJon F Watchko
Feb 6, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kaiying GuoYiying Zhang
Apr 1, 2005·Fish Physiology and Biochemistry·F SakaiB Senthilkumaran
Sep 16, 2014·Developmental Neurobiology·Maryline LecointreIsabelle Leroux-Nicollet
Jan 19, 2019·Cellular and Molecular Neurobiology·Belen BrieDamasia Becu-Villalobos
Dec 31, 2004·Stroke; a Journal of Cerebral Circulation·Patricia D HurnHenrik Hagberg
Feb 12, 2008·Cellular and Molecular Neurobiology·Victoria A Lux-LantosCarlos Libertun
Jul 30, 2014·Developmental Neurobiology·Tiffany GrecoMayumi L Prins
May 19, 2000·Neuroscience and Biobehavioral Reviews·L P Spear
Feb 11, 2004·Experimental Neurology·Aristea S Galanopoulou, Solomon L Moshé
Aug 10, 2021·Frontiers in Neurology·Lindsay FergusonMayumi L Prins
Apr 1, 2008·Hormones and Behavior·Eileen M FoeckingJon E Levine
Sep 8, 2009·Molecular and Cellular Endocrinology·Yiying Zhang

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