Brain single photon emission computed tomography imaging in Landau-Kleffner syndrome

Epilepsia
M M GuerreiroC A Guerreiro

Abstract

Five right-handed children with Landau-Kleffner syndrome (LKS) who had disease onset between the ages of 3 and 9 years were studied with EEG and single-photon emission computed tomography (SPECT) before and, in four cases, after 6 months of corticosteroid treatment. EEG findings included both focal and generalized spikes as well as spike-wave discharges with bilateral temporal predominance. These increased markedly during sleep in 1 child, and continuous spike-and-wave complexes appeared during slow-wave sleep in another patient. Neuropsychological testing demonstrated verbal auditory agnosia. Magnetic resonance imaging (MRI) was performed in 4 children and was normal. Brain SPECT imaging demonstrated abnormal perfusion in the left temporal lobe in all patients. The response to corticosteroid therapy was mixed. Our findings reinforce the concept that LKS is a functional disease affecting the language-dominant brain areas. We conclude that SPECT imaging may be of diagnostic assistance in the evaluation of this syndrome of unknown etiology.

References

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Citations

Jul 1, 1997·Brain & Development·N Gordon
Jun 17, 1999·Pediatric Neurology·C A SzabóY G Comair
Oct 7, 2003·Epilepsy & Behavior : E&B·Eric H KossoffJohn M Freeman
May 22, 2002·Revista de neurologia·M J PabloA Sáenz de Cabezón
Mar 4, 1999·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C P DohertyH Staunton
Oct 21, 1998·Electroencephalography and Clinical Neurophysiology·S SeriF Pisani
Aug 17, 2004·Epilepsy Currents·Phillip L. PearlGregory L. Holmes
Nov 9, 2011·Seminars in Pediatric Neurology·Shaun Hussain, Raman Sankar
Jun 18, 2003·Human Brain Mapping·Steve MajerusMarie-Noëlle Metz-Lutz
Jun 1, 1997·Seminars in Pediatric Neurology·R F Tuchman
Apr 25, 2000·Seizure : the Journal of the British Epilepsy Association·N Gordon
Jan 16, 1998·Journal of Child Neurology·E A da SilvaH T Chugani
Sep 24, 1998·Developmental Medicine and Child Neurology·M E O'ReganM Clarke

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