Sep 1, 1978

Brain specific benzodiazepine receptors

The British Journal of Psychiatry : the Journal of Mental Science
C Braestrup, R F Squires

Abstract

Brain membranes from rat and human contain a single class of brain specific binding sites for pharmacologically and clinically active benzodiazepines. There is good correlation between the pharmacological effects of benzodiazepines and the affinity for the 3H-diazepam binding site. Benzodiazepine binding sites are not present on glial cells. Selective neuronal degeneration experiments in rats indicate a neuronal localization. 3H-Flunitrazepam is a very suitable ligand for affinity binding and it binds to the same class of binding sites as 3H-diazepam. Our results indicate that the in vitro 3H-diazepam and 3H-flunitrazepam binding sites are the receptors which in vivo mediate various pharmacological and clinical effects of benzodiazepines.

Mentioned in this Paper

Establishment and Maintenance of Localization
Abnormal Degeneration
Tissue Membrane
Brain
Neuroglia
Receptors, Drug
Benzodiazepine [EPC]
Neuronal
Flunitrazepam-ratiopharm
Binding (Molecular Function)

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