Brain-specific lipids from marine, lacustrine, or terrestrial food resources: potential impact on early African Homo sapiens

Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
C Leigh BroadhurstWalter F Schmidt

Abstract

The polyunsaturated fatty acid (PUFA) composition of the mammalian central nervous system is almost wholly composed of two long-chain polyunsaturated fatty acids (LC-PUFA), docosahexaenoic acid (DHA) and arachidonic acid (AA). PUFA are dietarily essential, thus normal infant/neonatal brain, intellectual growth and development cannot be accomplished if they are deficient during pregnancy and lactation. Uniquely in the human species, the fetal brain consumes 70% of the energy delivered to it by mother. DHA and AA are needed to construct placental and fetal tissues for cell membrane growth, structure and function. Contemporary evidence shows that the maternal circulation is depleted of AA and DHA during fetal growth. Sustaining normal adult human brain function also requires LC-PUFA.Homo sapiens is unlikely to have evolved a large, complex, metabolically expensive brain in an environment which did not provide abundant dietary LC-PUFA. Conversion of 18-carbon PUFA from vegetation to AA and DHA is considered quantitatively insufficient due to a combination of high rates of PUFA oxidation for energy, inefficient and rate limited enzymatic conversion and substrate recycling. The littoral marine and lacustrine food chains provide consi...Continue Reading

References

Feb 28, 1976·Lancet·M A CrawfordG Williams
Dec 1, 1975·The Proceedings of the Nutrition Society·A J Sinclair
Feb 1, 1975·Pharmacological Research Communications·G P MesseriC Galli
Jan 1, 1976·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·M A CrawfordA J Sinclair
Aug 29, 1992·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·H J Deacon
Aug 29, 1992·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J D Clark
Oct 1, 1992·Scientific American·R J Blumenschine, J A Cavallo
Oct 1, 1992·Early Human Development·A A LeafM A Crawford
Nov 29, 1991·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R J Blumenschine
Nov 29, 1991·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R A Foley, P C Lee
Nov 29, 1991·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·K O'Dea
Dec 1, 1991·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Y T van der SchouwH J Huisjes
Mar 1, 1990·The American Journal of Clinical Nutrition·S D PhinneyR T Holman
May 1, 1987·The British Journal of Nutrition·J LeytonM A Crawford
Jan 1, 1986·Progress in Lipid Research·D C Kuhn, M Crawford
Oct 1, 1995·The American Journal of Clinical Nutrition·L J StevensJ R Burgess
Jul 1, 1995·The American Journal of Clinical Nutrition·J R Hibbeln, N Salem
Feb 1, 1995·Journal of Neurochemistry·H Jurevics, P Morell
Apr 1, 1995·The American Journal of Clinical Nutrition·J P Flatt
Aug 1, 1994·The American Journal of Clinical Nutrition·M MakridesR A Gibson
Jul 19, 1994·Proceedings of the National Academy of Sciences of the United States of America·H M McHenry
Feb 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·S E CarlsonE A Tolley
Jul 1, 1995·European Journal of Obstetrics, Gynecology, and Reproductive Biology·G HornstraM M Foreman-van Drongelen
Jun 1, 1996·The Journal of Nutrition·S B EatonM Shostak
Jan 1, 1997·The Journal of Nutrition·S C Cunnane, M J Anderson
Feb 1, 1997·American Journal of Physical Anthropology·W R Leonard, M L Robertson
Apr 1, 1997·European Journal of Clinical Nutrition·S B EatonM J Konner
Oct 23, 1997·The British Journal of Nutrition·W M RatnayakeP Laffey

❮ Previous
Next ❯

Citations

Aug 25, 2011·Brain Structure & Function·Eric LewitusPatrick R Hof
Oct 7, 2003·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·David J A JenkinsVladimir Vuksan
Oct 7, 2003·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Yiqun WangJulius Leyton
Oct 7, 2003·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Stephen C Cunnane, Michael A Crawford
Jan 14, 2003·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·N N SushchikG S Kalachova
Sep 24, 2010·The British Journal of Nutrition·Remko S KuipersFrits A J Muskiet
Jun 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·Teresa E Steele
Sep 26, 2013·Proceedings of the National Academy of Sciences of the United States of America·Maelán Fontes-VillalbaLoren Cordain
Jul 28, 2006·The British Journal of Nutrition·John H Langdon
Nov 2, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Benjamin L Hart
Jun 18, 2011·Lipids in Health and Disease·Ann B MoserJoseph G Hacia
Jun 24, 2011·Lipids in Health and Disease·Vincent J T van GinnekenWillem A Brandenburg
Apr 23, 2011·Lipids in Health and Disease·Afaf K El-AnsaryLayla Y Al-Ayahdi
Oct 3, 2012·PloS One·Rasika A MathiasFloyd H Chilton
Apr 1, 2011·Allergy & Rhinology·Faria KhanCarla McGuire Davis
Oct 19, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Joanne BradburyStephen P Myers
Aug 31, 2014·Trends in Ecology & Evolution·Carlos M Duarte
Aug 11, 2012·European Journal of Nutrition·Martine F LuxwoldaFrits A J Muskiet
May 5, 2009·Wiener klinische Wochenschrift·Alexander StröhleAndreas Hahn
Mar 19, 2013·Prostaglandins & Other Lipid Mediators·Michail I GladyshevOlesia N Makhutova
Jan 1, 2011·Journal of Environmental Sciences (China)·Pierre J ObeidJohn Hanna El-Nakat
May 27, 2008·Prostaglandins, Leukotrienes, and Essential Fatty Acids·E C Borsonelo, J C F Galduróz
Jun 26, 2013·Maternal & Child Nutrition·William Day Lassek, Steven J C Gaulin
Jul 1, 2013·Wiley Interdisciplinary Reviews. Cognitive Science·Dahlia W Zaidel
Dec 29, 2004·Physiology & Behavior·Caspar Wenk
Aug 30, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Marianna MazzaSalvatore Mazza
Jul 29, 2004·Nutritional Neuroscience·K NaliwaikoA C Ferraz
Aug 12, 2014·Journal of Human Evolution·Amy L Bauernfeind, Courtney C Babbitt
May 31, 2011·Pharmacology, Biochemistry, and Behavior·Rita MatteiMarcelo P Barros
Dec 5, 2012·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Michael A CrawfordWalter F Schmidt
May 13, 2011·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Remko S KuipersFrits A J Muskiet
Mar 17, 2015·Critical Reviews in Food Science and Nutrition·Aliza H StarkMichael A Crawford

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.