Brain stem activation of the hippocampus: a role for the magnocellular reticular formation and the MLF

Electroencephalography and Clinical Neurophysiology
R P Vertes

Abstract

In previous reports (Vertes 1977, 1979) we have shown that cells of the medial magnocellular reticular formation (MMRF) discharge at high rates of activity during both waking-movement and REM sleep and at low rates during quiet waking and slow wave sleep. We suggest that some of these reticular cells may be involved in the generation of the hippocampal theta rhythm since they fire maximally during the identical states (general movement and REM sleep) in which theta is present in the hippocampus of the rat. In the present study the influence of the brain stem on the hippocampus was analyzed by systematically mapping the entire brain stem with stimulation to determine its effect on hippocampal slow wave activity. The results showed that the most effective stimulation sites for eliciting hippocampal synchronization were those within the medial magnocellular reticular formation and in or near the medial longitudinal fasciculus (MLF) at the level of the pons. These results suggest that cells of the MMRF are critically involved in hippocampal theta generation and that the fibers of these theta-eliciting cells primarily ascend in the MLF in their route rostrally from the brain stem.

References

May 1, 1976·Electroencephalography and Clinical Neurophysiology·T PaivaW Mollevanger
Sep 1, 1976·Brain Research Bulletin·G G Berntson, D J Micco
Mar 1, 1974·Electroencephalography and Clinical Neurophysiology·J Winson
Apr 1, 1969·Electroencephalography and Clinical Neurophysiology·C H Vanderwolf
Aug 1, 1972·Behavioral Biology·J Winson
Jul 1, 1974·The Journal of Comparative Neurology·L C ConradD W Pfaff
Aug 12, 1970·Brain Research·P Polc, M Monnier
Jul 1, 1965·Electroencephalography and Clinical Neurophysiology·H PETSCHEP A VANZWIETEN

❮ Previous
Next ❯

Citations

Jan 1, 1989·Neir̆ofiziologiia = Neurophysiology·V S Gurfinkel'M A Lebedev
Aug 1, 1982·Electroencephalography and Clinical Neurophysiology·L W LeungW J Wadman
Jun 1, 1984·Electroencephalography and Clinical Neurophysiology·J LermaJ M Solís
Dec 1, 1990·Electroencephalography and Clinical Neurophysiology·M SteriadeM M Mesulam
Jan 1, 1982·Progress in Neurobiology·R P Vertes
Jan 1, 1984·Progress in Neurobiology·R P Vertes
Jan 1, 1986·Progress in Neurobiology·B H Bland
Aug 1, 1993·Progress in Neurobiology·B H Bland, L V Colom
Mar 1, 1988·Neuroscience·R P Vertes
Jan 1, 1991·Brain Research Bulletin·A J Heynen, R S Sainsbury
May 14, 1998·Neuroscience and Biobehavioral Reviews·S D Oddie, B H Bland
Jul 5, 2006·The European Journal of Neuroscience·A NuñezV Teruel
Jan 18, 2005·Behavioral and Cognitive Neuroscience Reviews·Robert P VertesGonzalo Viana Di Prisco
Sep 9, 2005·Hippocampus·Robert P Vertes

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.