Brain-stem auditory evoked responses to hypercarbia in preterm infants

Electroencephalography and Clinical Neurophysiology
H E FrissM R Wolfson

Abstract

To determine the effect of acute hypercarbia on brain-stem function in preterm neonates, we compared brain-stem auditory evoked responses (BAERs) during 8% CO2 breathing to those elicited during room air breathing in 12 healthy preterm infants during the first week of life. End-tidal CO2 (ETpCO2), respiratory rate and depth were monitored throughout the protocol. Absolute wave latencies and interpeak intervals of the BAERs were analyzed from duplicate trials. During 8% CO2 breathing, ETpCO2, respiratory rate and depth of respiration increased significantly (P < 0.05). The absolute latency of wave V was prolonged (P < 0.025) in the hypercarbic state as compared to baseline. Interpeak interval III-V was also prolonged (P < 0.025). Values of absolute peak latencies I and III were unaffected by the hypercarbic state. These data demonstrate that elevations in pCO2 which elicit ventilatory responses also effect the BAER. The specific effects on ventilatory pattern, peak V latency and interpeak interval III-V indicate brain-stem responsiveness and alterations in the more central components of the auditory pathway. These findings raise important considerations regarding the influence of hypercarbia on brain-stem function in preterm inf...Continue Reading

References

Mar 1, 1979·Pediatric Research·R L Bucciarelli, D V Eitzman
Oct 1, 1986·Electroencephalography and Clinical Neurophysiology·H SohmerK Goitein
Jul 1, 1989·The Journal of Pediatrics·E N KraybillJ H Khan
Mar 1, 1985·Electroencephalography and Clinical Neurophysiology·A KrumholzE McKenzie
Mar 1, 1987·Acta paediatrica Scandinavica·S A CalvertS C Forsyth
May 1, 1982·Electroencephalography and Clinical Neurophysiology·H SohmerR Chisin
Feb 1, 1983·Electroencephalography and Clinical Neurophysiology·H SohmerP Fainmesser
Jul 1, 1984·Electroencephalography and Clinical Neurophysiology·H SohmerG Havatselet
Jan 1, 1982·Annals of the New York Academy of Sciences·K Hecox, R Burkard
May 1, 1984·Journal of Neurosurgery·B K Siesjö
Feb 17, 1983·The New England Journal of Medicine·D J Henderson-SmartD J Campbell
Jun 1, 1983·Archives of Neurology·J E StockardB F Westmoreland
Aug 1, 1982·The Journal of Pediatrics·J L RobertsR E Marshall
Jun 1, 1981·Archives of Disease in Childhood·R W Cooke

❮ Previous
Next ❯

Citations

Dec 18, 2001·Pediatric Pulmonology·M VarugheseJ Whitehall
Nov 5, 2005·Respirology : Official Journal of the Asian Pacific Society of Respirology·Cengiz OzgeMukadder Calikoğlu
Jan 1, 1996·Archives of Disease in Childhood. Fetal and Neonatal Edition·M J TaylorJ Laugier
Aug 22, 2008·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Yuksel KaplanSerpil Ocal
Jun 19, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Ze D JiangAndrew R Wilkinson
Dec 9, 2004·Pediatric Research·Karen I FritzMaria Delivoria-Papadopoulos
Sep 5, 2006·Clinics in Perinatology·Karen I Fritz, Maria Delivoria-Papadopoulos

❮ Previous
Next ❯

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.