Abstract
Lesions of the brain stem in sporadic CJD were histopathologically and immunohistochemically investigated using an anti-PrP antibody on ten consecutive autopsy cases. Three major histopathological changes, spongiform changes, neuronal loss and hypertrophic astrocytosis, were employed as parameters of the alterations. The quadrigeminal plate and pontine nuclei were the most severely and consistently affected structures, and immunoreactivity against PrP was seen in these structures. There existed some discrepancies between the severity of the lesions and the intensity of the immunoreactivity against PrP. The medulla oblongata essentially remained normal on histopathological examination, but the inferior olivary nucleus showed prominent PrP deposition. Although the general view that pathological alterations in the brain stem are relatively mild in sporadic CJD was confirmed in this study, lesions of variable degrees which might influence a patient's clinical course were still observed in many structures in the brain stem.
References
Jun 1, 1978·Brain : a Journal of Neurology·C L Masters, E P Richardson
Nov 18, 1989·The Veterinary Record·G A WellsG P David
Dec 1, 1987·Journal of the Neurological Sciences·H MizusawaJ F Llena
Feb 1, 1981·Journal of Neurology, Neurosurgery, and Psychiatry·T MizutaniH Shiraki
Aug 1, 1995·Annals of Neurology·P BrownR Roos
Jan 1, 1995·Brain Pathology·G A Wells, J W Wilesmith
Apr 6, 1996·Lancet·R G WillP G Smith
Jun 1, 1996·Annals of Neurology·P ParchiP Gambetti
Oct 1, 1996·Brain Pathology·J W Ironside
Oct 1, 1995·Brain Pathology·H BudkaK Jellinger
Jan 1, 1997·Brain Pathology·J A HainfellnerH Budka
Feb 15, 1997·The Veterinary Record·J L WoodR Bradley
Aug 10, 2000·Histopathology·J W IronsideR G Will
Citations
May 2, 2009·The Cerebellum·Oren S CohenIsak Prohovnik
Mar 28, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Minjung SongHye-Jin Park
Aug 24, 2013·Rinshō shinkeigaku = Clinical neurology·Kishin KohYoshihisa Takiyama
Oct 13, 2015·BioMed Research International·Diego IaconoSalvatore Monaco
Mar 3, 2015·Neuropathology and Applied Neurobiology·Renata ReisColm Cunningham
Jan 13, 2017·Journal of Virology·Taichi HamanakaKatsumi Doh-Ura
Apr 22, 2020·The International Journal of Neuroscience·Grammatiki KatsikakiSevasti Bostantjopoulou
Nov 13, 2020·Curēus·Andre GrangerElina Zakin