Brain stem magnetic resonance imaging and evoked potential studies of symptomatic multiple sclerosis patients

European Neurology
G ComiN Canal

Abstract

In this study we evaluated the sensitivity of neuroradiological and neurophysiological tests for detecting brain stem (BS) lesions in multiple sclerosis patients, since the recent introduction of the gradient motion rephasing technique has markedly increased the image quality of magnetic resonance imaging (MRI). From 50 MS patients (33 women and 17 men; mean age 35.9 +/- 8.3 years; mean duration of the disease 7.2 +/- 4.1 years) with clinical signs of BS involvement, brain MRI, BS auditory evoked potentials (BAEPs), and left and right median somatosensory evoked potentials (mSEPs) were obtained. BS MRI lesions were detected in 41 patients (82%); in 14 cases they were located in the medulla oblongata, in 55 in the pons, and in 24 in the midbrain. Single lesions were present in 20 patients, while two or more BS lesions were demonstrated in 21 patients; 30 patients had at least one lesion located close to the inner or the outer cerebrospinal fluid border. BAEPs were abnormal in 19 of the 50 patients (38%), and BS components of mSEPs were abnormal in 15 of 46 (33%). With combined use of these neurophysiological techniques, BS abnormalities were revealed in 24 patients (48%). Only 1 patient had neurophysiological BS abnormalities an...Continue Reading

Citations

Oct 4, 2008·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Letizia Leocani, Giancarlo Comi
May 12, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·A SaariV Myllylä
Sep 16, 2009·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Agustina M LascanoChristoph M Michel
Jul 17, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·I NakashimaY Itoyama
Dec 27, 2016·Journal of the Neurological Sciences·Luka CrnošijaMario Habek
Sep 1, 1999·Multiple Sclerosis : Clinical and Laboratory Research·G ComiP Rossi
Mar 2, 2013·Expert Review of Neurotherapeutics·Mario Habek
May 26, 1998·Multiple Sclerosis : Clinical and Laboratory Research·N AccorneroL Capitanio
Jun 28, 2000·Current Opinion in Neurology·L Leocani, G Comi
Oct 8, 1998·Multiple Sclerosis : Clinical and Laboratory Research·G ComiS Medaglini
Aug 8, 2020·Multiple Sclerosis : Clinical and Laboratory Research·Ruth GeraldesUNKNOWN MAGNIMS study group

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