PMID: 3759533Oct 1, 1986Paper

Brain stem tumors in children: results of a survey of 62 patients treated with radiotherapy

International Journal of Radiation Oncology, Biology, Physics
C Freeman, S Suissa

Abstract

A survey was conducted by the Radiation Oncology Discipline Committee of the Pediatric Oncology Group to provide an estimate of the outcome of treatment with modern radiotherapy of brain stem tumors in children. Thirteen of thirty-eight institutions submitted data for 62 patients who had been diagnosed between 1972 and 1981, who had completed planned treatment with radiotherapy, and for whom follow-up information was available. The results were poor. Fourteen patients were alive with no evidence of recurrence between 11 and 154 (median 50.5) months post-treatment, two were alive with disease at 22 and 24 months, and forty-six died of disease at intervals ranging from 2 to 30 (median 8.7) months from initiation of treatment. Actuarial survival was 50% at 1 year, 29% at 2 years, and 23% at 5 years. The age of the patient, the surgical approach, and the volume and dose of radiotherapy all appeared to correlate with outcome on univariate analysis; but on multivariate analysis a statistically significant survival advantage was found only for patients greater than 5 years of age who had undergone surgery as part of their treatment. Possible explanations for these findings are discussed, and the roles of surgery, radiotherapy, and che...Continue Reading

References

Jul 1, 1975·Journal of Neurosurgery·F Lee
Jan 1, 1979·Child's Brain·D H ReigelJ E Woodford
Jul 1, 1985·International Journal of Radiation Oncology, Biology, Physics·E C Halperin
Aug 1, 1969·Radiology·T R WhyteD D Layton
Jun 1, 1971·Journal of Neurosurgery·K R LassiterD L Kelly
Aug 1, 1972·Radiology·R C Urtasun
Jan 1, 1980·International Journal of Radiation Oncology, Biology, Physics·T H KimJ H Webster
Jun 1, 1981·Journal of Neurosurgery·D S FultonC B Wilson
Mar 15, 1982·Cancer·R V MantravadiR Haas
Jul 1, 1982·International Journal of Radiation Oncology, Biology, Physics·H J Bloom
Dec 15, 1983·Cancer·A L AlbrightA N Guthkelch
Jun 1, 1982·International Journal of Radiation Oncology, Biology, Physics·G Kopelson, R Linggood
Jun 1, 1980·Cancer·P LittmanL Schut

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Citations

Nov 1, 1988·Journal of Neuro-oncology·S NishioJ Tateishi
Jun 1, 1992·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·B PakischH Leitner
Aug 1, 1993·Journal of Neuro-oncology·M E HebertO B Boyko
Feb 1, 1993·Journal of Neuro-oncology·M C Chamberlain
Apr 30, 1995·International Journal of Radiation Oncology, Biology, Physics·M D PradosV A Levin
Oct 31, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·D Schulz-ErtnerM Wannenmacher
Jun 1, 1997·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·C Fallai, P Olmi
Oct 13, 2001·International Journal of Radiation Oncology, Biology, Physics·B J FisherL Stitt
Mar 5, 1998·International Journal of Radiation Oncology, Biology, Physics·B DonahueR Pinto
Aug 1, 1988·International Journal of Radiation Oncology, Biology, Physics·C R FreemanD Norris
Jan 15, 2014·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Stefano Gabriele ValleroFranca Fagioli
May 12, 2007·Expert Review of Anticancer Therapy·David N Korones
Jan 1, 1993·Medical and Pediatric Oncology·C S BruggersJ M Hoffman
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·D C ShrieveV A Levin
Mar 1, 1989·International Journal of Radiation Oncology, Biology, Physics·P W GrigsbyB B Fineberg
Jul 1, 1989·International Journal of Radiation Oncology, Biology, Physics·Y ShibamotoM Abe
Jan 15, 1993·International Journal of Radiation Oncology, Biology, Physics·M J GuineyK Narayan
Sep 10, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S BaileyD Hargrave
Jun 22, 2016·Cancer·Sylvia C Eisele, David A Reardon
Mar 10, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sarah S DonaldsonPaul Graham Fisher
Jan 1, 1989·Medical and Pediatric Oncology·E C HalperinH S Friedman
Apr 1, 1993·Journal of Child Neurology·B L MariaN P Mendenhall
Jun 3, 1998·Journal of Neurosurgery·B J FisherD R Macdonald
Nov 28, 2001·Current Opinion in Neurology·J S GuillamoJ Y Delattre
Jan 1, 1994·Journal of Neuro-oncology·J Martinez-ClimentJ Ferris Tortajada
Jan 1, 1991·British Journal of Neurosurgery·S NishioM Fukui
Jan 1, 1990·Pediatric Hematology and Oncology·C M MandigersA G Theeuwes
Jan 1, 1991·Medical and Pediatric Oncology·M GriebelB Hockenberger

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