Brain stiffens post mortem.

Journal of the Mechanical Behavior of Biomedical Materials
J WeickenmeierE Kuhl

Abstract

Alterations in brain rheology are increasingly recognized as a diagnostic marker for various neurological conditions. Magnetic resonance elastography now allows us to assess brain rheology repeatably, reproducibly, and non-invasively in vivo. Recent elastography studies suggest that brain stiffness decreases one percent per year during normal aging, and is significantly reduced in Alzheimer's disease and multiple sclerosis. While existing studies successfully compare brain stiffnesses across different populations, they fail to provide insight into changes within the same brain. Here we characterize rheological alterations in one and the same brain under extreme metabolic changes: alive and dead. Strikingly, the storage and loss moduli of the cerebrum increased by 26% and 60% within only three minutes post mortem and continued to increase by 40% and 103% within 45 minutes. Immediate post mortem stiffening displayed pronounced regional variations; it was largest in the corpus callosum and smallest in the brainstem. We postulate that post mortem stiffening is a manifestation of alterations in polarization, oxidation, perfusion, and metabolism immediately after death. Our results suggest that the stiffness of our brain-unlike any o...Continue Reading

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Citations

Oct 21, 2018·Annals of Biomedical Engineering·Taylor C HarrisEllen Kuhl
May 2, 2020·The European Journal of Neuroscience·Chloe M HallGraham K Sheridan
Aug 21, 2020·Fluids and Barriers of the CNS·Ravi Teja KedarasettiFrancesco Costanzo
Jun 24, 2020·Scientific Reports·Ravi Teja KedarasettiFrancesco Costanzo
Jan 5, 2019·Soft Matter·Long QianHongwei Zhao
Dec 14, 2018·Micromachines·Long Qian, Hongwei Zhao
Dec 17, 2020·Acta Biomaterialia·Helge HerthumIngolf Sack
Dec 25, 2019·Biophysical Journal·Stephanie MöllmertJochen Guck
Jan 3, 2021·Journal of the Mechanical Behavior of Biomedical Materials·Efe OzkayaMehmet Kurt
Feb 23, 2021·Journal of Biomechanics·J D EscarcegaP V Bayly
Dec 31, 2019·Acta Biomaterialia·S BuddayG A Holzapfel
May 6, 2021·APL Bioengineering·Nicolas Marinval, Sing Yian Chew
Apr 20, 2021·Brain Multiphysics·Andrew K KnutsenDzung L Pham
Jul 17, 2021·Journal of the Mechanical Behavior of Biomedical Materials·E OzkayaM Kurt
Dec 14, 2021·PloS One·Victoria SpartacusCarolyn J Sparrey

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Methods Mentioned

BETA
rheology

Software Mentioned

Simpleware
SPM12

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