Brain structural abnormalities in patients with major depression with or without generalized anxiety disorder comorbidity

Journal of Neurology
Elisa CanuMassimo Filippi

Abstract

An overlap frequently occurs between major depression disorder (MDD) and generalized anxiety disorder (GAD). Aim of this study was to assess cortical and white matter (WM) alterations in MDD patients with or without GAD comorbidity. Seventy-one MDD patients and 71 controls were recruited. All subjects underwent T1-weighted and diffusion tensor (DT)/MRI. MRI metrics of cortical thickness and WM integrity were obtained from atlas-based cortical regions and the interhemispheric and major long association WM tracts. Between-group MRI comparisons and multiple regressions with clinical scale scores were performed. Compared to controls, both MDD and MDD-GAD patients showed a cortical thinning of the middle frontal cortex bilaterally, left medial frontal gyrus and frontal pole. Compared to controls and MDD patients, MDD-GAD cases also showed a thinning of the right medial orbitofrontal and fusiform gyri, and left temporal pole and lateral occipital cortices. Compared to controls, MDD patients showed DT MRI abnormalities of the right parahippocampal tract and superior longitudinal fasciculus bilaterally, while no WM alterations were found in MDD-GAD. In all patients, brain abnormalities were related with symptom severity. MDD and MDD-GA...Continue Reading

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Citations

Sep 15, 2015·Human Brain Mapping·Maria A RoccaMassimo Filippi
Mar 10, 2016·Human Brain Mapping·Milutin KosticMassimo Filippi
Nov 4, 2016·BMC Medicine·Howard J AizensteinOren Tene
Sep 18, 2015·Cephalalgia : an International Journal of Headache·Catherine D ChongTodd J Schwedt
Jul 4, 2020·Human Brain Mapping·Janna Marie Bas-HoogendamUNKNOWN ENIGMA-Anxiety Working Group
Nov 10, 2017·Current Opinion in Psychiatry·Roxanne GasperszBrenda W J H Penninx
Nov 4, 2017·Journal of Affective Disorders·Chavit TunvirachaisakulRobert J Howard
Aug 14, 2021·Journal of Psychiatric Research·Lisa SindermannElisabeth Johanna Leehr
Aug 18, 2018·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jee Su SuhBenicio N Frey
Aug 28, 2021·Social Cognitive and Affective Neuroscience·Alexander SoutschekPhilippe N Tobler
Sep 14, 2021·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Thomas M HessPhilippe N Tobler
May 23, 2019·Neuropsychobiology·Maxence ThomasVirginie Moulier

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