Brain structural and functional correlates of resilience to Bipolar Disorder.

Frontiers in Human Neuroscience
Sophia Frangou

Abstract

Resilient adaptation can be construed in different ways, but as used here it refers to adaptive brain responses associated with avoidance of psychopathology despite expressed genetic predisposition to Bipolar Disorder (BD). Although family history of BD is associated with elevated risk of affective morbidity a significant proportion of first-degree relatives remain free of psychopathology. Examination of brain structure and function in these individuals may inform on adaptive responses that pre-empt disease expression. Data presented here are derived from the Vulnerability to Bipolar Disorders Study (VIBES) which includes BD patients, asymptomatic relatives and controls. Participants underwent extensive investigations including brain structural (sMRI) and functional magnetic resonance imaging (fMRI). We present results from sMRI voxel-based-morphometry and from conventional and connectivity analyses of fMRI data obtained during the Stroop Colour Word Test (SCWT), a task of cognitive control during conflict resolution. All analyses were implemented using Statistical Parametric Mapping software version 5 (SPM5). Resilience in relatives was operationalized as the lifetime absence of clinical-range symptoms. Resilient relatives of ...Continue Reading

Citations

Sep 1, 2015·Neuroscience and Biobehavioral Reviews·Camille PiguetJosselin Houenou
Feb 11, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Gianna SepedeFrancesco Gambi
Feb 10, 2018·International Journal of Bipolar Disorders·David G AngelerMaj-Liz Persson
Nov 15, 2019·Bipolar Disorders·Kareen HeinzeHeather C Whalley
Jul 28, 2020·European Archives of Psychiatry and Clinical Neuroscience·Lisa RauerOliver Gruber
Jan 14, 2020·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Leila NabulsiDara M Cannon
Mar 7, 2021·Brain Sciences·Gianluca SerafiniDisease Management Team On Dementia Of The Irccs Ospedale Policlinico San Martino

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Software Mentioned

Statistical Parametric Mapping
SPSS
PickAtlas
SPM
SPM5
Matlab

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Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.