Brain structural changes in women and men during midlife

Neuroscience Letters
J Y GuoGraham K Murray

Abstract

Brain development during childhood and adolescence differs between boys and girls. Structural changes continue during adulthood and old age, particularly in terms of brain volume reductions that accelerate beyond age 35 years. We investigated whether brain structural change in mid-life differs between men and women. 43 men and 28 women from the Northern Finland 1966 Birth Cohort underwent MRI brain scans at age 33-35 (SD=0.67) and then again at age 42-44 (SD=0.41). We examined sex differences in total percentage brain volume change (PBVC) and regional brain change with FSL SIENA software. Women showed significant PBVC reduction compared with men between the ages of 33-35 and 42-44 years (Mean=-3.21% in men, Mean=-4.03% in women, F (1, 68)=6.37, p<0.05). In regional analyses, women exhibited greater brain reduction than men in widespread areas. After controlling for total percent brain volume change, men show greater relative regional brain reduction than women in bilateral precentral gyri, bilateral paracingulate gyri, and bilateral supplementary motor cortices. The results indicate sex differences in brain changes in mid-life. Women have more total brain reduction, and more reduction on the outer brain surface than men, wherea...Continue Reading

References

Jul 18, 1991·The New England Journal of Medicine·S F Witelson
Apr 1, 1982·Journal of the American Geriatrics Society·J HatazawaT Matsuzawa
Nov 22, 1997·IEEE Transactions on Medical Imaging·P A Freeborough, N C Fox
Feb 15, 2000·The American Journal of Psychiatry·H C KraemerD Kupfer
Jun 22, 2000·NeuroImage·J Ashburner, K J Friston
May 15, 2001·Journal of Computer Assisted Tomography·S M SmithP M Matthews
Dec 18, 2001·Human Brain Mapping·Thomas E Nichols, Andrew P Holmes
Jan 16, 2002·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Ruben C GurRaquel E Gur
Aug 17, 2002·Cerebral Cortex·Ruben C GurRaquel E Gur
Dec 20, 2003·NeuroImage·Satoru Hayasaka, Thomas E Nichols
Jun 16, 2006·Neurobiology of Aging·Charles D SmithWilliam R Markesbery
Oct 10, 2006·Proceedings of the National Academy of Sciences of the United States of America·Khanum RidlerEdward T Bullmore
Jan 24, 2007·The European Journal of Neuroscience·Patricia E CowellNeil Roberts
Nov 17, 2009·Brain and Cognition·Rhoshel K Lenroot, Jay N Giedd
Oct 5, 2010·NeuroImage·Jeroen de BresserMax A Viergever
Feb 10, 2011·The Journal of Neuropsychiatry and Clinical Neurosciences·Allison R KaupLisa T Eyler
Sep 15, 2011·Human Brain Mapping·Anna M HedmanHilleke E Hulshoff Pol
Oct 8, 2011·NeuroImage·Mark JenkinsonStephen M Smith
Nov 23, 2011·European Journal of Radiology·Hidemasa TakaoKuni Ohtomo
Feb 16, 2012·Gender Medicine·Joel SalinasPeg Nopoulos
Aug 23, 2012·Biology of Sex Differences·Jay N GieddRhoshel K Lenroot
Feb 18, 2014·NeuroImage·Anderson M WinklerThomas E Nichols

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Citations

Jul 13, 2016·Schizophrenia Research·Fay Y WomerDeanna M Barch
Apr 16, 2017·The Australian and New Zealand Journal of Psychiatry·Giuseppe DelvecchioPaolo Brambilla
Nov 6, 2018·Brain Structure & Function·S J LehtolaH Karlsson
May 11, 2018·Brain Imaging and Behavior·Rowa AljondiPatricia Desmond
May 14, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Piotr Gałecki, Monika Talarowska
Feb 23, 2021·Frontiers in Aging Neuroscience·Giuseppe DelvecchioPaolo Brambilla

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Software Mentioned

Statistical Parametric Mapping ( SPM )
FAST FMRIB Automated Segmentation Tool
FLIRT FMRIB Linear Image Registration Tool
SIENA
SIENA ( Structural Image Evaluation , using
SPSS
SIENA ( Structural Image Evaluation , using Normalisation )
FSL ( FMRIB Software Library )
Randomise FSL
SINEA

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