Brain structural correlates of obsessive-compulsive disorder with and without preceding stressful life events

The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry
Eva RealJosé M Menchón

Abstract

Objectives There is growing evidence supporting a role for stressful life events (SLEs) at obsessive-compulsive disorder (OCD) onset, but neurobiological correlates of such effect are not known. We evaluated regional grey matter (GM) changes associated with the presence/absence of SLEs at OCD onset. Methods One hundred and twenty-four OCD patients and 112 healthy controls were recruited. Patients were split into two groups according to the presence (n = 56) or absence (n = 68) of SLEs at disorder's onset. A structural magnetic resonance image was acquired for each participant and pre-processed with Statistical Parametric Mapping software (SPM8) to obtain a volume-modulated GM map. Between-group differences in sociodemographic, clinical and whole-brain regional GM volumes were assessed. Results SLEs were associated with female sex, later age at disorder's onset, more contamination/cleaning and less hoarding symptoms. In comparison with controls, patients without SLEs showed GM volume increases in bilateral dorsal putamen and the central tegmental tract of the brainstem. By contrast, patients with SLEs showed specific GM volume increases in the right anterior cerebellum. Conclusions Our findings support the idea that neuroanatomi...Continue Reading

References

Oct 1, 1977·Archives of General Psychiatry·N C AndreasenG Winokur
Sep 1, 1990·Journal of Personality and Social Psychology·N Bolger
Nov 1, 1989·Archives of General Psychiatry·W K GoodmanD S Charney
Nov 1, 1989·Archives of General Psychiatry·W K GoodmanD S Charney
Jun 1, 1986·The British Journal of Psychiatry : the Journal of Mental Science·P M MillerP G Surtees
Oct 1, 1971·Archives of General Psychiatry·E S PaykelE H Uhlenhuth
Jun 9, 1999·The American Journal of Psychiatry·K S KendlerC A Prescott
Feb 23, 2000·European Psychiatry : the Journal of the Association of European Psychiatrists·F BogettoL Ravizza
Dec 5, 2000·The British Journal of Psychiatry : the Journal of Mental Science·M Piccinelli, G Wilkinson
Mar 14, 2002·Depression and Anxiety·Christine LochnerDan J Stein
May 3, 2002·The American Journal of Psychiatry·Beth S GershunySabine Wilhelm
Mar 11, 2003·Physical Medicine and Rehabilitation Clinics of North America·Bryan Kolb
Sep 11, 2003·Current Opinion in Neurobiology·A D Craig
Jan 1, 1959·The British Journal of Medical Psychology·M HAMILTON
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Jul 9, 2004·Archives of General Psychiatry·Jesús PujolJulio Vallejo
Dec 22, 2004·Molecular Psychiatry·E C MiguelD L Pauls
Dec 31, 2004·Journal of Clinical Psychology·Han-Joo LeeSeok-Man Kwon
Jan 29, 2005·The American Journal of Psychiatry·David Mataix-ColsJames F Leckman
May 4, 2005·Archives of General Psychiatry·Terrie E MoffittMichael Rutter
Jun 9, 2005·Biological Psychiatry·Eric HollanderMonte Buchsbaum
Feb 8, 2007·The Journal of Clinical Psychiatry·Faruk UguzAli Savas Cilli
Feb 27, 2007·NeuroImage·Carles Soriano-MasChristian Gaser
Apr 17, 2007·Depression and Anxiety·Javier LabadJulio Vallejo
Aug 4, 2007·Behaviour Research and Therapy·Kiara R CromerDennis L Murphy
Sep 2, 2008·The British Journal of Psychiatry : the Journal of Mental Science·Samuel R ChamberlainBarbara J Sahakian
Oct 7, 2008·NeuroImage·Catherine J Stoodley, Jeremy D Schmahmann
Oct 28, 2008·Brain : a Journal of Neurology·Odile A van den HeuvelDick J Veltman
Jan 24, 2009·Brain Research Reviews·Markus ButzArjen van Ooyen
Aug 1, 2009·Science·Eduardo Dias-FerreiraNuno Sousa
Sep 25, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Bernard W Balleine, John P O'Doherty
Nov 3, 2009·The British Journal of Psychiatry : the Journal of Mental Science·Joaquim Radua, David Mataix-Cols
Feb 16, 2010·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Catherine J Stoodley, Jeremy D Schmahmann
Nov 3, 2010·The British Journal of Psychiatry : the Journal of Mental Science·Ronald C KesslerDavid R Williams

❮ Previous
Next ❯

Citations

Jul 28, 2019·Frontiers in Neuroendocrinology·Josep Moreno-Rius

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.