Brain structure and function correlates of cognitive subtypes in schizophrenia.

Psychiatry Research
Daniel GeislerStefan Ehrlich

Abstract

Stable neuropsychological deficits may provide a reliable basis for identifying etiological subtypes of schizophrenia. The aim of this study was to identify clusters of individuals with schizophrenia based on dimensions of neuropsychological performance, and to characterize their neural correlates. We acquired neuropsychological data as well as structural and functional magnetic resonance imaging from 129 patients with schizophrenia and 165 healthy controls. We derived eight cognitive dimensions and subsequently applied a cluster analysis to identify possible schizophrenia subtypes. Analyses suggested the following four cognitive clusters of schizophrenia: (1) Diminished Verbal Fluency, (2) Diminished Verbal Memory and Poor Motor Control, (3) Diminished Face Memory and Slowed Processing, and (4) Diminished Intellectual Function. The clusters were characterized by a specific pattern of structural brain changes in areas such as Wernicke's area, lingual gyrus and occipital face area, and hippocampus as well as differences in working memory-elicited neural activity in several fronto-parietal brain regions. Separable measures of cognitive function appear to provide a method for deriving cognitive subtypes meaningfully related to bra...Continue Reading

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Citations

Sep 20, 2016·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Andre F MarquandChristian F Beckmann
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Aug 26, 2020·Translational Psychiatry·Abraham NunesMartin Alda
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Apr 18, 2021·Asian Journal of Psychiatry·Mariachiara BuonocoreRoberto Cavallaro
Jun 16, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Helena PelinTill F M Andlauer

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