Brain structure and function related to headache: Brainstem structure and function in headache

Cephalalgia : an International Journal of Headache
Marta Vila-PueyoSimon Akerman

Abstract

To review and discuss the literature relevant to the role of brainstem structure and function in headache. Primary headache disorders, such as migraine and cluster headache, are considered disorders of the brain. As well as head-related pain, these headache disorders are also associated with other neurological symptoms, such as those related to sensory, homeostatic, autonomic, cognitive and affective processing that can all occur before, during or even after headache has ceased. Many imaging studies demonstrate activation in brainstem areas that appear specifically associated with headache disorders, especially migraine, which may be related to the mechanisms of many of these symptoms. This is further supported by preclinical studies, which demonstrate that modulation of specific brainstem nuclei alters sensory processing relevant to these symptoms, including headache, cranial autonomic responses and homeostatic mechanisms. This review will specifically focus on the role of brainstem structures relevant to primary headaches, including medullary, pontine, and midbrain, and describe their functional role and how they relate to mechanisms of primary headaches, especially migraine.

References

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Citations

May 3, 2019·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Domenico ChirchigliaRosa Marotta
Oct 28, 2019·Cephalalgia : an International Journal of Headache·Jan Hoffmann, Philip R Holland
Apr 18, 2020·Cephalalgia : an International Journal of Headache·Kuan-Lin LaiShuu-Jiun Wang
Jul 28, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Clément VerkestGuillaume Sandoz
Sep 23, 2018·The Journal of Headache and Pain·Anne Luise VollesenUNKNOWN School of Advanced Studies of the European Headache Federation (EHF-SAS)
Dec 22, 2020·World Neurosurgery·Maimaitijiang KasimuZhou Kai
Jun 3, 2021·International Journal of Molecular Sciences·Yi YeJennifer Gibbs
Oct 14, 2021·Cephalalgia : an International Journal of Headache·Simona NikolovaCatherine D Chong

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