Brain Structure Covariance Associated with Gait Control in Aging

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Gilles AllaliOlivier Beauchet

Abstract

Structural and functional brain imaging methods have identified age-related changes in brain structures involved in gait control. This cross-sectional study aims to investigate gray matter networks associated with gait control in aging using structural covariance analysis. Walking speed were measured in 326 non-demented older community-dwellers (age 71.3±4.5; 41.7% female) under three different walking conditions: normal walking and two challenging tasks: motor (i.e.; fast speed) and an attention-demanding dual task (i.e.; backward counting). Three main individual gray matter regions were positively correlated with walking speed (i.e.; slower walking speed was associated with lower brain volumes): right thalamus, right caudate nucleus and left middle frontal gyrus for normal walking, rapid walking and dual-task walking condition, respectively. The structural covariance analysis revealed that prefrontal regions were part of the networks associated with every walking condition; the right caudate was associated specifically with the hippocampus, amygdala and insula for the rapid walking condition and the left middle frontal gyrus with a network involving the cuneus for the dual-task condition. Our results suggest that brain networ...Continue Reading

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Citations

Mar 13, 2019·Journal of Internal Medicine·Q TianL Ferrucci
Mar 1, 2019·Journal of Alzheimer's Disease : JAD·Andrea L RossoCaterina Rosano
Apr 15, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Nemin ChenAndrea L Rosso
Mar 26, 2019·Journal of Alzheimer's Disease : JAD·Antoine LangeardLouis Bherer
Dec 8, 2020·Frontiers in Aging Neuroscience·Catherine Persephone AgathosAngelo Arleo
Mar 31, 2021·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Carissa GrijalvaKaveh Laksari

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