Brain structure mediates the association between height and cognitive ability

Brain Structure & Function
Eero VuoksimaaWilliam S Kremen

Abstract

Height and general cognitive ability are positively associated, but the underlying mechanisms of this relationship are not well understood. Both height and general cognitive ability are positively associated with brain size. Still, the neural substrate of the height-cognitive ability association is unclear. We used a sample of 515 middle-aged male twins with structural magnetic resonance imaging data to investigate whether the association between height and cognitive ability is mediated by cortical size. In addition to cortical volume, we used genetically, ontogenetically and phylogenetically distinct cortical metrics of total cortical surface area and mean cortical thickness. Height was positively associated with general cognitive ability and total cortical volume and cortical surface area, but not with mean cortical thickness. Mediation models indicated that the well-replicated height-general cognitive ability association is accounted for by individual differences in total cortical volume and cortical surface area (highly heritable metrics related to global brain size), and that the genetic association between cortical surface area and general cognitive ability underlies the phenotypic height-general cognitive ability relatio...Continue Reading

References

Jan 1, 1993·The American Journal of Psychiatry·N C AndreasenW T Yuh
Dec 1, 1996·Molecular Neurobiology·A J D'ErcoleG Gutierrez-Ospina
Sep 14, 2000·Proceedings of the National Academy of Sciences of the United States of America·B Fischl, A M Dale
Feb 24, 2001·Behavior Genetics·D PosthumaD Boomsma
Jan 31, 2002·Nature Neuroscience·Daniëlle PosthumaDorret I Boomsma
Dec 5, 2003·Cerebral Cortex·Bruce FischlAnders M Dale
Oct 27, 2004·NeuroImage·Bruce FischlAnders M Dale
Jul 12, 2005·Neurobiology of Aging·Kristine B WalhovdBruce Fischl
Jan 27, 2007·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·William S KremenMichael J Lyons
Mar 21, 2009·Cerebral Cortex·Matthew S PanizzonWilliam S Kremen
Nov 17, 2010·Hormone Research in Pædiatrics·E Maria LundgrenJan Gustafsson
Sep 24, 2011·Neuropsychologia·Christian K TamnesKristine B Walhovd
Jun 13, 2012·Proceedings of the National Academy of Sciences of the United States of America·Armin RaznahanJay N Giedd
Aug 4, 2012·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Lisa T EylerWilliam S Kremen
Nov 1, 2012·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·William S KremenMichael J Lyons
Apr 18, 2013·PLoS Genetics·Matthew C KellerBrendan P Zietsch
Jan 3, 2014·Human Brain Mapping·Rachel M BrouwerDorret I Boomsma
Mar 5, 2014·Cerebral Cortex·Amanda E LyallJohn H Gilmore
Jun 21, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andreas B StorsveKristine B Walhovd
Sep 30, 2014·The Journal of Pediatrics·Sara SammallahtiKatri Räikkönen
Nov 5, 2014·The British Journal of Psychiatry : the Journal of Mental Science·Tom C RussG David Batty
Jun 25, 2015·NeuroImage. Clinical·Anne Elisabeth SølsnesLars M Rimol
Oct 16, 2015·NeuroImage·Simon DucharmeUNKNOWN Brain Development Cooperative Group
Nov 18, 2015·Proceedings of the National Academy of Sciences of the United States of America·Anders M FjellKristine B Walhovd
Jul 20, 2016·Proceedings of the National Academy of Sciences of the United States of America·Kristine B WalhovdAnders M Fjell
Jul 28, 2016·ELife·UNKNOWN NCD Risk Factor Collaboration (NCD-RisC)
Mar 31, 2017·Developmental Psychology·Michael J LyonsHong Xian

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