Brain structures of a medaka mutant, el (eyeless), in which eye vesicles do not evaginate

Brain, Behavior and Evolution
Y IshikawaK Ozato

Abstract

Eye development and brain structures of a mutant teleost fish were investigated. The el (eyeless) mutation in medaka (Oryzias latipes) is recessive and affects eye formation; in the most severe cases, it results in the absence of eyes. Developmental studies revealed that normal eyeballs are not formed in the el mutant embryos, but small optic cup-like structures differentiate in situ in the walls of the prosencephalon without evagination. The anophthalmic el homozygous fish hatched normally, although they did not respond behaviorally to visual stimuli. A small fraction of these fish grew to adulthood. In the adult anophthalmic el homozygous fish, the brain exhibited abnormalities in several subdivisions. A pair of small abnormal protrusions was observed on the surface of the ventral telencephalon and preoptic area. Immunocytochemistry using a rhodopsin monoclonal antibody showed that opsin-positive cells were present in the abnormal structures. Bodian staining showed that the optic nerves were present near the abnormal structures, although the number of optic nerve fibers was extremely small. The optic tectum was extremely small, and the thickness of the stratum opticum and stratum fibrosum et griseum superficiale was reduced. ...Continue Reading

Citations

Apr 28, 2005·Developmental Neuroscience·Daphne SoaresWilliam R Jeffery
Jun 7, 2005·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Tomohiro MasudaKatsumi Aida
Jun 9, 2004·Developmental Biology·Breandán N KennedySusan E Brockerhoff
May 13, 2011·Developmental Neurobiology·Kara L CervenyStephen W Wilson
Sep 22, 2006·Journal of Radiation Research·Takako YasudaYuji Ishikawa
Oct 1, 2021·Biology Open·Lucie DevosSylvie Rétaux

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