Brain temperature responses to salient stimuli persist during dopamine receptor blockade despite a blockade of locomotor responses.

Pharmacology, Biochemistry, and Behavior
Eugene A Kiyatkin

Abstract

We examined how an acute dopamine (DA) receptor blockade affects locomotor and brain (nucleus accumbens or NAcc), muscle and skin temperature responses to three arousing stimuli (procedure of sc injection, tail-pinch and social interaction with another male rat) and intravenous cocaine (1 mg/kg). DA receptor blockade was induced by mixture of D1- (SCH23390) and D-2 selective (eticlopride) DA antagonists at 0.2 mg/kg doses. Each arousing stimulus and cocaine caused locomotor activation, prolonged increase in NAcc and muscle temperature (0.6-1.0 degrees C for 20-50 min) and transient skin hypothermia (-0.6 degrees C for 1-3 min) in drug-naive conditions. DA receptor blockade strongly decreased basal locomotor activity, but moderately increased brain, muscle and skin temperatures. Therefore, selective interruption of DA transmission does not inhibit the brain, making it more metabolically active and warmer despite skin vasodilatation and the enhanced heat loss to the body and the external environment. DA antagonists strongly decreased locomotor responses to all stimuli and cocaine, had no effects on acute skin vasoconstriction, but differentially affected stimuli- and drug-induced changes in NAcc and muscle temperatures. While bra...Continue Reading

References

Feb 1, 1976·The American Journal of Physiology·M A BakerD G Mountjoy
Jan 1, 1991·Physiological Reviews·M Le Moal, H Simon
Jan 20, 1987·European Journal of Pharmacology·J E Faunt, A D Crocker
Jan 9, 1999·European Journal of Pharmacology·J Poon, M van den Buuse
Oct 29, 2000·Trends in Neurosciences·P CalabresiG Bernardi
Aug 1, 1964·Angiology·G F SOLOMONW J FESSEL
Mar 1, 1951·Circulation·M D ALTSCHULE
May 14, 2005·Brain Research. Brain Research Reviews·Eugene A Kiyatkin
Aug 24, 2005·The European Journal of Neuroscience·Eugene A Kiyatkin, P Leon Brown
Sep 22, 2006·The European Journal of Neuroscience·François Windels, Eugene A Kiyatkin
Oct 19, 2006·The Journal of Emergency Medicine·Joanne Williams, Jonathan Wasserberger

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Citations

Oct 20, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Annetrude J G de Mooij-van MalsenMartien J H Kas
Apr 20, 2010·Pharmacology, Biochemistry, and Behavior·Caterina MarcangionePaul B S Clarke
Oct 27, 2017·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L M S CordeiroD D Soares
Jan 15, 2020·Temperature : Multidisciplinary Biomedical Journal·Eugene A Kiyatkin
Oct 1, 2014·Temperature : Multidisciplinary Biomedical Journal·Eugene A Kiyatkin
May 22, 2021·Journal of Thermal Biology·Binney SharmaHruda Nanda Mallick

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