Brain Tissue Oxygenation in Patients with Septic Shock: a Feasibility Study

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
Michael WoodJ Gordon Boyd

Abstract

Delirium is common in critically ill patients and its presence is associated with increased mortality and increased likelihood of poor cognitive function among survivors. However, the cause of delirium is unknown. The purpose of this study was to demonstrate the feasibility of using near-infrared spectroscopy (NIRS) to assess brain tissue oxygenation in patients with septic shock, who are at high risk of developing delirium. This prospective observational study was conducted in a 33-bed general medical surgical intensive care unit (ICU). Patients with severe sepsis or septic shock were eligible for recruitment. The FORESIGHT NIRS monitor was used to assess brain tissue oxygenation in the frontal lobes for the first 72 hours of ICU admission. Physiological data was also recorded. We used the Confusion Assessment Method-ICU to screen for delirium. From March 1st 2014-September 30th 2014, 10 patients with septic shock were recruited. The NIRS monitor captured 81% of the available data. No adverse events were recorded. Brain tissue oxygenation demonstrated significant intra- and inter-individual variability in the way it correlated with physiological parameters, such as mean arterial pressure, heart rate, and peripheral oxygen satu...Continue Reading

References

Apr 15, 2004·JAMA : the Journal of the American Medical Association·E Wesley ElyRobert S Dittus
Jul 15, 2005·Current Opinion in Critical Care·Pratik PandharipandeE Wesley Ely
Dec 21, 2006·Anesthesia and Analgesia·John M MurkinStephanie Fox
Feb 14, 2008·Seminars in Cardiothoracic and Vascular Anesthesia·André DenaultJohn M Murkin
Mar 4, 2008·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Carlos Javier RegazzoniJuan Jose Poderoso
May 7, 2008·Critical Care : the Official Journal of the Critical Care Forum·David PfisterLuzius A Steiner
Sep 23, 2008·Neurocritical Care·Luzius A SteinerMarek Czosnyka
Nov 7, 2009·Critical Care Clinics·Alan E Jones, Michael A Puskarich
Dec 17, 2009·British Journal of Anaesthesia·J M Murkin, M Arango
May 11, 2010·Archives of Gerontology and Geriatrics·Zeev ArinzonYitshal Noam Berner
May 18, 2010·Critical Care Medicine·Timothy D GirardE Wesley Ely
May 27, 2010·Brain Imaging and Behavior·Mary R SuchytaRamona O Hopkins
Nov 30, 2011·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Terri Marin, James Moore
Jun 20, 2012·Critical Care Medicine·Max L GuntherUNKNOWN VISIONS Investigation, VISualizing Icu SurvivOrs Neuroradiological Sequelae
Oct 23, 2012·American Journal of Respiratory and Critical Care Medicine·Christopher W SeymourDerek C Angus
Nov 9, 2012·Journal of Neurology, Neurosurgery, and Psychiatry·Alexander SemmlerMichael T Heneka
Dec 28, 2012·Critical Care Medicine·Juliana BarrUNKNOWN American College of Critical Care Medicine
Jan 31, 2013·Intensive Care Medicine·R P DellingerUNKNOWN Surviving Sepsis Campaign Guidelines Committee including The Pediatric Subgroup
Apr 20, 2013·Scandinavian Journal of Infectious Diseases·Merete StorgaardAnnmarie T Lassen
Aug 30, 2013·The New England Journal of Medicine·Derek C Angus, Tom van der Poll
Sep 27, 2013·Virulence·Daniel De BackerJean-Louis Vincent
Oct 4, 2013·The New England Journal of Medicine·P P PandharipandeUNKNOWN BRAIN-ICU Study Investigators
Nov 26, 2013·Paediatric Anaesthesia·John P Scott, George M Hoffman
Oct 2, 2014·The New England Journal of Medicine·Sandra L PeakePatricia Williams

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Citations

Feb 10, 2016·The Journal of Pharmacology and Experimental Therapeutics·Clark R SimsPhilip R Mayeux
Jun 3, 2017·International Journal of Geriatric Psychiatry·Anita NitchinghamGideon A Caplan
Mar 17, 2020·EMBO Molecular Medicine·Jean-Marc CavaillonTomasz Skirecki
May 3, 2019·Intensive Care Medicine Experimental·Michael D WoodUNKNOWN Cerebral Oxygenation and Neurological Outcomes Following Critical Illness (CONFOCAL) Research Group
Apr 4, 2017·Critical Care : the Official Journal of the Critical Care Forum·David M MasloveDaren K Heyland
Feb 23, 2020·Journal of Intensive Care Medicine·Elina VarisErika Wilkman
May 22, 2021·Canadian Journal of Kidney Health and Disease·Jessica Anne VanderlindenJohn Gordon Boyd

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