Brain tissue pressure gradients created by expanding frontal epidural mass lesion

Journal of Neurosurgery
C E WolflaT K Putty

Abstract

A porcine model was used to study the regional intracranial pressure (ICP) differences caused by a frontal mass lesion. Intraparenchymal ICP monitors were placed in the right and left frontal lobes, right and left temporal lobes, midbrain, and cerebellum. A frontal epidural mass lesion was created by placing a balloon catheter through a burr hole into the right frontal epidural space. A computer was used to acquire data from all monitors at 50-msec intervals. The balloon was expanded by 1 cc over a period of 1 second every 5 minutes and maximum pressure immediately before and during expansion was determined for each balloon volume at each site. Prior to expansion of the mass, the morphology of the cerebellum pressure tracing was different from that seen in all supratentorial regions. Also, pressures in the midbrain, at baseline, were slightly but significantly lower than pressures in the frontal and temporal regions. During expansion of the mass, a pressure differential that increased as the size of the mass increased developed between intracranial regions. Furthermore, the regional pressures were found to vary in a consistent fashion expressed by the formula RF=LF>RT=LT>MB>CB, in which RF and LF are the right and left frontal ...Continue Reading

References

Mar 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·D I GrahamD R McLellan
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Citations

Dec 31, 2002·Surgical Neurology·Anthony L D'AmbrosioE Sander Connolly
Mar 27, 2001·Computer Methods in Biomechanics and Biomedical Engineering·MICHAEL I. MigaDAVID W. Roberts
Jan 22, 2011·Journal of Neurotrauma·Peter E BatchelorDavid W Howells
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Nov 5, 1997·Seminars in Pediatric Neurology·T G Luerssen
May 26, 2017·British Journal of Neurosurgery·Vicente VanaclochaLeyre Vanaclocha
Sep 22, 2010·British Journal of Neurosurgery·Paul GiganteE Sander Connolly
Nov 5, 2005·AACN Clinical Issues·Karen March
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Apr 30, 2019·Frontiers in Neurology·Edson Bor-Seng-ShuFernando Mendes Paschoal
Jul 26, 2019·Neurocritical Care·Nathan MohneyAmedeo Merenda

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