Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease

Science
Ronald B DeMattosDavid M Holtzman

Abstract

The deposition of amyloid-beta (Abeta) peptides into amyloid plaques precedes the cognitive dysfunction of Alzheimer's disease (AD) by years. Biomarkers indicative of brain amyloid burden could be useful for identifying individuals at high risk for developing AD. As in AD in humans, baseline plasma Abeta levels in a transgenic mouse model of AD did not correlate with brain amyloid burden. However, after peripheral administration of a monoclonal antibody to Abeta (m266), we observed a rapid increase in plasma Abeta and the magnitude of this increase was highly correlated with amyloid burden in the hippocampus and cortex. This method may be useful for quantifying brain amyloid burden in patients at risk for or those who have been diagnosed with AD.

Associated Clinical Trials

References

Mar 11, 1999·Annals of Neurology·J L Price, J C Morris
Mar 1, 2000·Proceedings of the National Academy of Sciences of the United States of America·D M HoltzmanS M Paul
Mar 29, 2000·JAMA : the Journal of the American Medical Association·J NäslundJ D Buxbaum
Mar 29, 2001·Physiological Reviews·D J Selkoe
Jul 5, 2001·Proceedings of the National Academy of Sciences of the United States of America·R B DeMattosD M Holtzman
Sep 18, 2001·Archives of Neurology·J L PriceJ C Morris

❮ Previous
Next ❯

Citations

Nov 9, 2011·Archives of General Psychiatry·Anand KumarGary W Small
May 7, 2008·Archives of General Psychiatry·Xiaoyan SunWei Qiao Qiu
Jan 11, 2005·Neurotoxicity Research·Gillian C Gregory, Glenda M Halliday
May 13, 2008·Cellular and Molecular Life Sciences : CMLS·E MalitoW-J Tang
Jul 9, 2004·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Jan G SchiltzKarin Moelling
Sep 17, 2011·Der Nervenarzt·R ZimmermannP Lewczuk
Jul 16, 2010·Acta Neuropathologica·Delphine BocheJames A R Nicoll
Jul 3, 2013·Acta Neuropathologica·Michal Arbel-OrnathBrian J Bacskai
Feb 1, 2005·Journal of Neural Transmission·P H LeeK Huh
Feb 23, 2012·Journal of Neural Transmission·Robert A RissmanPaul S Aisen
Feb 24, 2010·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Kazunori KawaguchiSatoshi Sugiyama
Dec 6, 2012·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Kazunori KawaguchiNobuya Kitaguchi
May 25, 2005·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Melvin K SimmonsMichael C Montalto
Jun 11, 2008·Neuromolecular Medicine·Esther S OhStina M Fangmark Tucker
Apr 4, 2013·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Y Joy Yu, Ryan J Watts
Jul 22, 2004·Brain, Behavior, and Immunity·William A BanksSteven S Zalcman
Oct 29, 2013·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Bian-Sheng JiLing He
Dec 31, 2003·Journal of Molecular Biology·Justin LegleiterTomasz Kowalewski
Apr 6, 2005·Trends in Neurosciences·Berislav V Zlokovic
Jul 29, 2005·The American Journal of Pathology·Samir Kumar-SinghChristine Van Broeckhoven
Oct 24, 2003·FEBS Letters·Baolin LiBinhui Ni
Dec 21, 2002·Pharmacology & Therapeutics·Yoshihisa Kitamura, Yasuyuki Nomura
Jan 25, 2003·Experimental Gerontology·Brian P Lockhart, Pierre J Lestage
Mar 27, 2003·Trends in Molecular Medicine·Jean-Cosme DodartSteven M Paul
Nov 26, 2003·Lancet Neurology·Chiara BrianiGilberto Pizzolato
May 28, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Yinxing LiuLouis B Hersh
Jun 3, 2008·Nature Medicine·Terrence TownRichard A Flavell
Sep 23, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alena V SavonenkoDon L Price
Aug 2, 2007·Nature Reviews. Drug Discovery·Romeo CecchelliLaurence Fenart
Mar 2, 2010·Nature Reviews. Drug Discovery·Adriano Aguzzi, Tracy O'Connor
Aug 20, 2011·Nature Reviews. Drug Discovery·Eric KarranBart De Strooper
Jan 25, 2007·Nature Reviews. Molecular Cell Biology·Christian Haass, Dennis J Selkoe
Apr 22, 2004·Nature Reviews. Neuroscience·Costantino Iadecola
Jul 5, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Aaron C HirkoJeffery A Hughes

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.