Brain-tumor cell kinetics correlated with survival

Journal of Neurosurgery
J W BookwalterM Kristofik

Abstract

In a review of 38 glioblastoma patients for whom fresh tissue kinetic data were available before any therapy was instituted, no correlation between the labeling index and survival time could be statistically determined. This relationship seems entirely consistent with the published theoretical determinants of tumor behavior: that is, altered ability for growth arrest and differentiation, constantly evolving mutant sublines, genetic instability, and an ever-changing metabolic and vascular environment.

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Citations

Oct 20, 2005·Journal of Neuro-oncology·Shaye I MoskowitzRichard A Prayson
Mar 1, 1996·International Journal of Radiation Oncology, Biology, Physics·F G BarkerC B Wilson
Aug 1, 1991·Journal of Neurosurgery·E C Alvord
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Jan 11, 1992·British Journal of Neurosurgery·P CarboniR Postans
Jul 9, 1991·International Journal of Cancer. Journal International Du Cancer·M DanovaA Riccardi

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Methods Mentioned

BETA
biopsy

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