Brain tumor stem cells as therapeutic targets in models of glioma.

Yonsei Medical Journal
Dan Richard LaksHarley Ian Kornblum

Abstract

At this time, brain tumor stem cells remain a controversial hypothesis while malignant brain tumors continue to present a dire prognosis of severe morbidity and mortality. Yet, brain tumor stem cells may represent an essential cellular target for glioma therapy as they are postulated to be the tumorigenic cells responsible for recurrence. Targeting oncogenic pathways that are essential to the survival and growth of brain tumor stem cells represents a promising area for developing therapeutics. However, due to the multiple oncogenic pathways involved in glioma, it is necessary to determine which pathways are the essential targets for therapy. Furthermore, research still needs to comprehend the morphogenic processes of cell populations involved in tumor formation. Here, we review research and discuss perspectives on models of glioma in order to delineate the current issues in defining brain tumor stem cells as therapeutic targets in models of glioma.

References

Oct 1, 1976·Science·P C Nowell
Nov 15, 1988·Cancer·C Daumas-DuportP Kelly
Dec 20, 1994·Proceedings of the National Academy of Sciences of the United States of America·M I ChiuV Berlin
Sep 1, 1996·Medical Hypotheses·E D Schwab, K J Pienta
Sep 10, 1998·Journal of the National Cancer Institute·M A SmithR Simon
Nov 6, 1998·Molecular Pharmacology·H HosoiP J Houghton
Apr 3, 2001·Annual Review of Neuroscience·R Wechsler-Reya, M P Scott
May 18, 2001·Nature·J Taipale, P A Beachy
Nov 2, 2001·Nature·T ReyaI L Weissman
Nov 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·S K RehenJ Chun
Jun 8, 2002·Annual Review of Neuroscience·Nicholas Gaiano, Gord Fishell
Jul 3, 2002·Nature Reviews. Cancer·Igor Vivanco, Charles L Sawyers
Sep 14, 2002·Science·Natalia B IvanovaIhor R Lemischka
Oct 3, 2002·Neuro-oncology·Margaret WrenschMitchel S Berger
Feb 13, 2003·Brain Pathology·Paul S Mischel, Timothy F Cloughesy
Dec 3, 2003·Proceedings of the National Academy of Sciences of the United States of America·Houman D HemmatiHarley I Kornblum
Jan 23, 2004·Nature Reviews. Cancer·Ricardo PardalSean J Morrison
Mar 3, 2004·Nature Reviews. Cancer·Hiroaki Kitano
May 4, 2004·Nature Reviews. Cancer·Mary-Ann Bjornsti, Peter J Houghton
Sep 21, 2004·Oncogene·Sheila K SinghPeter B Dirks
Sep 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·C Hirschmann-JaxM K Brenner
Oct 12, 2004·Cancer·Kenneth R HessMelissa L Bondy
Nov 5, 2004·Cellular and Molecular Life Sciences : CMLS·C WieseA M Wobus
Mar 11, 2005·The New England Journal of Medicine·Roger StuppUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Apr 2, 2005·Nature Reviews. Cancer·Michael DeanSusan Bates
Jul 21, 2005·Theoretical Biology & Medical Modelling·Fabio Grizzi, Maurizio Chiriva-Internati
Aug 3, 2005·The Journal of Cell Biology·Ichiro NakanoHarley I Kornblum
Aug 27, 2005·The New England Journal of Medicine·Nader SanaiMitchel S Berger
Jan 7, 2006·Cancer Research·Cho-Lea TsoStanley F Nelson
Feb 3, 2006·Cancer Research·Kathryn E O'ReillyNeal Rosen
Feb 17, 2006·Cancer Cell International·Fabio Grizzi, Maurizio Chiriva-Internati
Mar 22, 2006·Pediatric Research·Ichiro Nakano, Harley I Kornblum
May 3, 2006·Cancer Research·Sathish Kumar MungamuriKumaravel Somasundaram
Jun 27, 2006·Nature·Andreas Androutsellis-TheotokisRonald D G McKay
Aug 26, 2006·Nature Clinical Practice. Neurology·Judith A SchwartzbaumMargaret Wrensch
Aug 30, 2006·Proceedings of the National Academy of Sciences of the United States of America·Robert AxelrodKenneth J Pienta
Sep 23, 2006·The New England Journal of Medicine·Craig T JordanMark Noble
Nov 9, 2006·Proceedings of the National Academy of Sciences of the United States of America·S HorvathP S Mischel

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Citations

May 10, 2011·Investigational New Drugs·Zahid M DelwarJuan Sebastian Yakisich
Jan 29, 2013·Molekuliarnaia biologiia·N V GubanovaP M Chumakov
Oct 23, 2012·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Ding-Yang LiuXing-Jun Jiang
Jun 26, 2012·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Ting SunZiwei Du
Apr 10, 2012·Biotechnology Advances·Razia NoreenCyril Petibois
Aug 29, 2012·ISRN Oncology·M H CruzJ S Yakisich
Mar 19, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ellen KlauserHasso Seibert
Aug 13, 2013·Medical Hypotheses·Alessandro Fontana, Borys Wróbel
Apr 28, 2016·Neuro-oncology·Dan R LaksHarley I Kornblum
May 14, 2017·Cancer Chemotherapy and Pharmacology·Anna M Bielecka-WajdmanEwa Obuchowicz
Jul 6, 2017·Oncology Reports·Xianghe LuWenfeng Li
Jun 16, 2017·Environmental Toxicology·Antonietta ArcellaGiampaolo Cantore
Dec 24, 2018·Nanomedicine·Agostina GrilloneGianni Ciofani
Aug 10, 2021·World Journal of Stem Cells·Vivek KaushikJuan Sebastian Yakisich

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Methods Mentioned

BETA
surgical resection
biopsies
biopsy

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