PMID: 7546012May 1, 1995Paper

Brain tumors associated with infantile spasms

Pediatric Neurology
H AsanumaS Chiba

Abstract

Two patients with brain tumors associated with infantile spasms are reported. Both infants displayed typical clinical features of infantile spasms, comprising tonic spasms manifesting in series and hypsarrythmia. In Patient 1, magnetic resonance imaging revealed a tumor in the hypothalamic region, suggestive of hypothalamic hamartoma. In Patient 2, cranial computed tomography and magnetic resonance imaging indicated the existence of a primary brain tumor with calcification in the right temporal lobe. Adrenocorticotropic hormone therapy combined with clonazepam relieved seizures in both infants. In Patient 1, resection of the hypothalamic tumor is impossible because the tumor lacks a stalk. In Patient 2, pathologic investigation of removed tumor tissue demonstrated mixed-oligoastrocytoma. It is suggested that focal lesions, like those in our patients, are involved in the development of infantile spasms.

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Citations

Sep 30, 2010·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Tomoko MizunoMasumi Inagaki
Mar 17, 2004·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Göran BrandbergOrvar Eeg-Olofsson
Oct 18, 2000·Pediatric Neurology·S HamanoS Kohno
Nov 7, 1998·Pediatric Neurology·E Wyllie
Aug 15, 2014·Indian Journal of Pediatrics·Ajay Gupta
Apr 9, 1998·Brain & Development·K Watanabe
Jun 17, 1998·Brain & Development·B F Bourgeois
Oct 17, 1998·La Revue de médecine interne·C LebrunM Frenay
Jan 24, 2007·Epilepsia·John F KerriganHarold L Rekate
Feb 1, 1997·Journal of Child Neurology·G AktanS Aysun
Apr 6, 1999·Journal of Child Neurology·G IncorporaE Parano
Aug 2, 2017·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Uğur IşıkM Memet Özek
Nov 11, 2020·Journal of Child Neurology·Cemal KarakasIrfan Ali
Nov 12, 2019·Seizure : the Journal of the British Epilepsy Association·Jun T Park, Guadalupe Fernandez-Baca Vaca

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