Brain tumour targeting strategies via coated ferrociphenol lipid nanocapsules

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Anne-Laure LainéCatherine Passirani

Abstract

In this study, a new active targeting strategy to favour ferrociphenol (FcdiOH) internalisation into brain tumour cells was developed by the use of lipid nanocapsules (LNCs) coated with a cell-internalising peptide (NFL-TBS.40-63 peptide) that interacts with tubulin-binding sites. In comparison, OX26 murine monoclonal antibodies (OX26-MAb) targeting transferrin receptors were also inserted onto the LNC surface. The incorporation of OX26 or peptide did not influence the in vitro antiproliferative effect of FcdiOH-LNCs on the 9L cells since their IC50 values were found in the same range. In vivo, intracerebral administration of OX26-FcdiOH-LNCs or peptide-FcdiOH-LNCs by convection enhanced delivery did not enhance the animal median survival time in comparison with untreated rats (25 days). Interestingly, intra-carotid treatment with peptide-FcdiOH-LNCs led to an ameliorated survival time of treated rats with the presence of animals surviving until days 35, 40 and 44. Such results were not obtained with OX26-MAbs, demonstrating the benefit of NFL-TBS.40-63 peptide as an active ligand for peripheral drug delivery to the brain tumours.

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Citations

Jul 11, 2013·Nanomedicine·Christian Oliver PritzRudolf Glueckert
Feb 20, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Reatul KarimGeraldine Piel
Jun 1, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·A-L LainéC Passirani
May 23, 2012·Current Opinion in Pharmacology·Anne-Laure Lainé, Catherine Passirani
Jul 24, 2015·Neuro-oncology·Jean-Michel LeméePhilippe Menei
Oct 19, 2013·Nanomedicine : Nanotechnology, Biology, and Medicine·Laura Saenz del BurgoJose Luis Pedraz
May 16, 2015·Seminars in Pediatric Neurology·Christos D KatsetosPavel Dráber
May 21, 2014·Nanomedicine : Nanotechnology, Biology, and Medicine·Anne-Laure LainéCatherine Passirani
Sep 11, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Basil MujokoroMasood Khosravani
Oct 22, 2015·Chemical Society Reviews·Gérard JaouenSiden Top
Nov 19, 2013·Pharmaceutical Patent Analyst·Gerardo CarusoMaria Caffo
Jan 16, 2020·Cancers·Basant Salah MahmoudChristopher McConville
Jun 9, 2020·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Elise LepeltierCatherine Passirani
Jun 19, 2021·International Journal of Pharmaceutics·Griveau AudreyEyer Joel

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