Brain type I but not type II IL-1 receptors mediate the effects of IL-1 beta on behavior in mice

The American Journal of Physiology
S CremonaP Parnet

Abstract

In the immune system, interleukin (IL)-1 beta effects are mediated by the type I IL-1 receptors (IL-1RI), whereas the type II IL-1 receptors (IL-1RII) act as inhibitory receptors. IL-1RI and IL-1RII are also present in the brain. To study their functionality in the brain, mice were centrally treated with neutralizing monoclonal antibody (MAb) directed against IL-1RI (35F5, 1 microgram) or against IL-1RII (4E2, 2 micrograms) and were centrally injected with recombinant rat IL-1 beta at a dose (2 ng) that decreased social exploration. Only 35F5 was effective in abrogating the behavioral effect of IL-1 beta. Moreover, 4E2 (1 microgram i.c.v.) did not potentiate the behavioral response to a subthreshold dose of IL-1 beta (1 ng i.c.v.). To examine the ability of brain IL-1RI to mediate the effects of endogenous IL-1 beta, mice were centrally treated with 35F5 (4 micrograms) and peripherally injected with IL-1 beta (1 microgram). Like IL-1 receptor antagonist (4 micrograms i.c.v.), 35F5 abrogated the effects of IL-1 beta. These results suggest that brain IL-1RI mediates the behavioral effects of IL-1 beta in mice.

References

Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J E GershenwaldL L Moldawer
Nov 1, 1991·The Journal of Clinical Investigation·W P Arend
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R ChizzoniteU Gubler
Dec 1, 1994·Immunology Today·F ColottaA Mantovani
Nov 1, 1994·Brain Research. Molecular Brain Research·P ParnetK W Kelley

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Citations

Jul 18, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·S LayéP Parnet
May 20, 2009·Pharmacogenomics·Clive Bowman, Olivier Delrieu
Jan 26, 1999·Annals of the New York Academy of Sciences·R DantzerK W Kelley

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