Brain volume change and cognitive trajectories in aging

Neuropsychology
Evan FletcherDan Mungas

Abstract

Examine how longitudinal cognitive trajectories relate to brain baseline measures and change in lobar volumes in a racially/ethnically and cognitively diverse sample of older adults. Participants were 460 older adults enrolled in a longitudinal aging study. Cognitive outcomes were measures of episodic memory, semantic memory, executive function, and spatial ability derived from the Spanish and English Neuropsychological Assessment Scales (SENAS). Latent variable multilevel modeling of the four cognitive outcomes as parallel longitudinal processes identified intercepts for each outcome and a second order global change factor explaining covariance among the highly correlated slopes. We examined how baseline brain volumes (lobar gray matter, hippocampus, and white matter hyperintensity) and change in brain volumes (lobar gray matter) were associated with cognitive intercepts and global cognitive change. Lobar volumes were dissociated into global and specific components using latent variable methods. Cognitive change was most strongly associated with brain gray matter volume change, with strong independent effects of global gray matter change and specific temporal lobe gray matter change. Baseline white matter hyperintensity and hi...Continue Reading

Citations

Oct 27, 2018·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Brandon E GavettSid E O'Bryant
Jan 25, 2020·Journal of the International Neuropsychological Society : JINS·Teresa FilshteinSarah Farias
Dec 6, 2019·Frontiers in Neuroscience·Sven HallerPanteleimon Giannakopoulos
Feb 11, 2020·Journal of Alzheimer's Disease : JAD·Kaitlin B CasalettoLaura B Zahodne
Jul 19, 2019·Frontiers in Aging Neuroscience·François R HerrmannPanteleimon Giannakopoulos
May 7, 2019·Frontiers in Aging Neuroscience·Annlia Paganini-HillMark J Fisher
Jan 19, 2021·Journal of the International Neuropsychological Society : JINS·Dan MungasSarah Tomaszewski Farias
Feb 7, 2021·BMC Geriatrics·Noah D KoblinskyNicole D Anderson
Nov 17, 2020·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Kelli L SullivanSteven Paul Woods
Apr 26, 2021·Brain : a Journal of Neurology·Evan FletcherUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Apr 13, 2021·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Hector Hernandez SaucedoDan Mungas
Oct 16, 2020·Journal of Neuropsychology·Shayne S-H LinUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Jul 13, 2021·Journal of Women & Aging·Georgina L MorenoNatalie L Denburg
May 19, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kristen M GeorgeRachel A Whitmer
Aug 14, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kristen M GeorgeRachel A Whitmer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Aging

Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.