Brain volumes and cerebrovascular lesions on MRI in patients with atherosclerotic disease. The SMART-MR study

Atherosclerosis
Mirjam I GeerlingsSMART Study Group

Abstract

To estimate brain volumes, white matter lesion (WML) volume and asymptomatic infarcts on MRI in a large cohort of patients with atherosclerotic disease. Within the SMART-MR (Second Manifestations of ARTerial disease-Magnetic Resonance) study, a prospective cohort study on determinants and course of brain changes on MRI, cross-sectional analyses were performed in 1044 patients (mean age 58+/-10 years, 80% male) with coronary artery disease, cerebrovascular disease, peripheral arterial disease, or abdominal aortic aneurysm. Brain segmentation was used to quantify volumes of cortical gray matter, white matter, sulcal and ventricular cerebrospinal fluid, and WML. All volumes were expressed relative to intracranial volume. Brain infarcts were rated visually and distinctions were made between cortical infarcts, large subcortical infarcts, lacunar infarcts, and infarcts in the cerebellum and brainstem. With older age a nonlinear (quadratic) decrease in total brain volume was observed and a nonlinear increase in ventricular volume and WML. Cortical gray matter volume showed a linear decrease with age and was stronger in men than in women. WML volumes also increased more strongly in men than in women, while ventricular volume decrease s...Continue Reading

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Citations

Aug 26, 2010·Psychological Medicine·Rikke B DalbyPoul Videbech
Mar 22, 2012·Psychosomatic Medicine·Anne M GroolUNKNOWN SMART Study Group
Jun 25, 2014·Journal of the Neurological Sciences·Laura E M WisseUNKNOWN SMART-MR Study Group
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Jan 1, 2012·JRSM Cardiovascular Disease·Julia SlarkPankaj Sharma
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Mar 26, 2015·Stroke; a Journal of Cerebral Circulation·Pieternella H van der VeenUNKNOWN SMART Study Group

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