Brain volumes, RBC status, and hepatic function in alcoholics after 1 and 4 weeks of sobriety: predictors of outcome

The American Journal of Psychiatry
A PfefferbaumE V Sullivan

Abstract

The authors asked if hematological indices of RBC status and hepatic function in newly sober alcoholic men are related to abnormalities in brain morphology, change with normalization of brain function during short-term sobriety, and predict prolonged sobriety. Alcoholic men received brain magnetic resonance imaging and laboratory assessments on admission and before discharge from an inpatient treatment program. Healthy comparison men were similarly tested. On admission, RBC count, hemoglobin level, and hematocrit were significantly lower in alcoholic subjects than comparison subjects; mean corpuscular volume, SGOT, SGPT, and gamma-glutamyl transpeptidase were significantly higher. By discharge, all measures had improved, although RBC count, mean corpuscular volume, and gamma-glutamyl transpeptidase levels remained significantly different from those of comparison subjects. Upon admission, alcoholic men had smaller cortical white and gray matter and larger lateral and third ventricle volumes, with reduced lateral ventricle and increased anterior cortical gray matter volumes by discharge. Lower RBC count, hemoglobin level, and hematocrit were associated with lower white matter and higher ventricular volumes at admission. Change in...Continue Reading

Citations

Jan 24, 2009·European Archives of Psychiatry and Clinical Neuroscience·Thomas WobrockWolfgang Gaebel
Jan 26, 2006·Journal of the International Neuropsychological Society : JINS·Robert J ThomaJose M Cañive
Sep 27, 2008·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Timothy C DurazzoDieter J Meyerhoff
Dec 11, 2008·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Edith V Sullivan, Adolf Pfefferbaum
Dec 13, 2005·Topics in Magnetic Resonance Imaging : TMRI·M Vittoria SpampinatoFernando Descartes
Mar 31, 2012·Addiction Biology·Mollie A MonnigBarbara S McCrady
Jun 24, 2006·Alcoholism, Clinical and Experimental Research·Adolf PfefferbaumEdith V Sullivan
Oct 15, 2011·Alcoholism, Clinical and Experimental Research·Chun-Hsin ChenDaniel W Hommer
Nov 23, 2010·Alcoholism, Clinical and Experimental Research·Stefan GazdzinskiDieter J Meyerhoff
Aug 30, 2005·Biological Psychiatry·Adolf PfefferbaumEdith V Sullivan
Nov 25, 2016·Alcoholism, Clinical and Experimental Research·Timothy C Durazzo, Dieter J Meyerhoff
Apr 23, 2019·Journal of Neuroscience Research·Michael FritzNatalie M Zahr

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