Brain volumetric changes and cognitive ageing during the eighth decade of life

Human Brain Mapping
Stuart J RitchieIan J Deary

Abstract

Later-life changes in brain tissue volumes--decreases in the volume of healthy grey and white matter and increases in the volume of white matter hyperintensities (WMH)--are strong candidates to explain some of the variation in ageing-related cognitive decline. We assessed fluid intelligence, memory, processing speed, and brain volumes (from structural MRI) at mean age 73 years, and at mean age 76 in a narrow-age sample of older individuals (n = 657 with brain volumetric data at the initial wave, n = 465 at follow-up). We used latent variable modeling to extract error-free cognitive levels and slopes. Initial levels of cognitive ability were predictive of subsequent brain tissue volume changes. Initial brain volumes were not predictive of subsequent cognitive changes. Brain volume changes, especially increases in WMH, were associated with declines in each of the cognitive abilities. All statistically significant results were modest in size (absolute r-values ranged from 0.114 to 0.334). These results build a comprehensive picture of macrostructural brain volume changes and declines in important cognitive faculties during the eighth decade of life.

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Jul 28, 1997·The Journal of Comparative Neurology·B Pakkenberg, H J Gundersen
Aug 23, 2001·Medical Image Analysis·M Jenkinson, S Smith
Jan 1, 1957·The Journal of Nervous and Mental Disease·J WILDER
Jan 14, 2004·Journal of Personality and Social Psychology·Linda S Gottfredson
Jan 22, 2004·Nature Reviews. Neuroscience·Trey Hedden, John D E Gabrieli
Jul 28, 2004·NeuroImage·Ian J DearyJoanna M Wardlaw
Jun 18, 2005·Neurobiology of Aging·An-Tao DuMichael W Weiner
Aug 23, 2005·PLoS Medicine·Fiona MatthewsUNKNOWN Medical Research Council Cognitive Function and Ageing Study Investigators
Jul 4, 2007·Neuropsychology·Joel H KramerHelena C Chui
Jul 28, 2007·The Behavioral and Brain Sciences·Rex E Jung, Richard J Haier
Dec 21, 2007·Nature Reviews. Neuroscience·Charles H HillmanArthur F Kramer
Jul 19, 2008·Stroke; a Journal of Cerebral Circulation·Ewoud J van DijkMonique M B Breteler
Sep 27, 2008·Annual Review of Psychology·John J McArdle
May 19, 2009·Neurobiology of Aging·V A CardenasM W Weiner
Jul 3, 2009·Neurobiology of Aging·Kristine B WalhovdAnders M Fjell
Jul 10, 2009·Developmental Psychology·Elliot M Tucker-Drob
Jul 17, 2010·NeuroImage·E A MurphyUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Oct 1, 2010·Reviews in the Neurosciences·Anders M Fjell, Kristine B Walhovd
Jan 20, 2011·Developmental Psychology·Elliot M Tucker-Drob
Feb 9, 2011·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·Wendy JohnsonIan J Deary
Apr 6, 2011·Psychological Bulletin·Timothy A Salthouse
Nov 25, 2011·International Journal of Stroke : Official Journal of the International Stroke Society·Joanna M WardlawIan J Deary
Jan 19, 2012·International Journal of Epidemiology·Ian J DearyJohn M Starr
Feb 22, 2012·Alzheimer Disease and Associated Disorders·Liana G ApostolovaPaul M Thompson
Jun 21, 2012·Nature Reviews. Neuroscience·Cheryl Grady
Oct 16, 2012·Brain : a Journal of Neurology·J A SchneiderD A Bennett
Nov 2, 2012·European Radiology·Benjamin S AribisalaJoanna M Wardlaw
Nov 17, 2012·Cerebrovascular Diseases·Xin WangJoanna M Wardlaw
Jun 15, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Leslie WolfsonWilliam B White
Jul 16, 2013·Neurobiology of Aging·Natalie A RoyleJoanna M Wardlaw
Jul 23, 2013·Lancet Neurology·Joanna M WardlawUNKNOWN STandards for ReportIng Vascular changes on nEuroimaging (STRIVE v1)
Jul 31, 2013·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Kathryn V PappLeslie Wolfson

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Citations

May 5, 2016·Neurobiology of Aging·David Alexander DickieJoanna M Wardlaw
Jul 28, 2016·Neurobiology of Aging·Robert J DawePatricia A Boyle
Apr 26, 2017·Molecular Psychiatry·J H ColeI J Deary
May 14, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·François De GuioHugues Chabriat
Sep 8, 2017·Brain Structure & Function·Simon R CoxIan J Deary
Dec 5, 2018·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Maria Del C Valdés HernándezUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Mar 5, 2017·Neurology·James H ColeUNKNOWN COBRA collaboration
Dec 22, 2019·Brain Structure & Function·L JänckeS Merillat
Dec 27, 2017·Alzheimer Disease and Associated Disorders·Deepti VibhaMohammad A Ikram
Apr 12, 2019·Frontiers in Neurology·Benedikt M FreyGötz Thomalla
Apr 21, 2017·Brain Structure & Function·Stuart J RitchieIan J Deary
Mar 17, 2018·International Journal of Epidemiology·Adele M TaylorIan J Deary
Apr 23, 2019·Stroke; a Journal of Cerebral Circulation·Annick WyssDavid Alexander Dickie
Apr 20, 2018·International Journal of Stroke : Official Journal of the International Stroke Society·David Alexander DickieJoanna M Wardlaw
Aug 14, 2019·Frontiers in Psychiatry·Ian J DearyMark E Bastin
Jun 14, 2019·Reviews in the Neurosciences·Jessica OschwaldSusan Mérillat
Dec 2, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Carola MayerBastian Cheng
Feb 4, 2021·Molecular Psychiatry·Ian J DearyW David Hill
Apr 16, 2021·NeuroImage. Clinical·Maria Gloria RossettiValentina Lorenzetti
Oct 16, 2021·GigaScience·Kamalaker DadiDenis Engemann

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