Brain Wiring and Supragranular-Enriched Genes Linked to Protracted Human Frontal Cortex Development.

Cerebral Cortex
J. P. HendyChristine J Charvet

Abstract

The human frontal cortex is unusually large compared with many other species. The expansion of the human frontal cortex is accompanied by both connectivity and transcriptional changes. Yet, the developmental origins generating variation in frontal cortex circuitry across species remain unresolved. Nineteen genes that encode filaments, synapse, and voltage-gated channels are especially enriched in the supragranular layers of the human cerebral cortex, which suggests enhanced corticocortical projections emerging from layer III. We identify species differences in connections with the use of diffusion MR tractography as well as gene expression in adulthood and in development to identify developmental mechanisms generating variation in frontal cortical circuitry. We demonstrate that increased expression of supragranular-enriched genes in frontal cortex layer III is concomitant with an expansion in corticocortical pathways projecting within the frontal cortex in humans relative to mice. We also demonstrate that the growth of the frontal cortex white matter and transcriptional profiles of supragranular-enriched genes are protracted in humans relative to mice. The expansion of projections emerging from the human frontal cortex arises b...Continue Reading

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Citations

Jun 21, 2020·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Christine J Charvet
May 27, 2021·Seminars in Cell & Developmental Biology·Anne Teissier, Alessandra Pierani
Dec 28, 2021·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·David A Leopold, Bruno B Averbeck

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