Brains with sporadic Creutzfeldt-Jakob disease and copathology showed a prolonged end-stage of disease

Journal of Clinical Pathology
Aitzol Miguelez-RodriguezIvan Fernandez-Vega

Abstract

To investigate the expression of major proteins related to primary neurodegenerative diseases and their prognostic significance in brains with Creutzfeldt-Jakob disease (CJD). Thirty consecutive cases of confirmed CJD during the period 2010-2015 at Basque Brain bank were retrospectively reviewed. Moreover, major neurodegenerative-associated proteins (phosphorylated Tau, 4R tau, 3R tau, alpha-synuclein, TDP43, amyloid beta) were tested. Clinical data were reviewed. Cases were divided according to the presence or absence of copathology. Survival curves were also determined. Copathology was significantly associated with survival in brains with CJD (4.2±1.2 vs 9.2±1.9; P=0.019) and in brains with MM1/MV1 CJD (2.1±1.0 vs 6.7±2.8; P=0.012). Besides, the presence of more than one major neurodegenerative-associated protein was significantly associated with survival (4.2±1.2 vs 10.7±2.6; P=0.017). Thus, univariate analyses further pointed out variables significantly associated with better survival: copathology in CJD (HR=0.430; P=0.033); more than one neurodegenerative-associated protein in CJD (HR=0.369; P=0.036) and copathology in MM1/MV1 CJD (HR=0.525; P=0.032). The existence of copathology significantly prolongs survival in patients...Continue Reading

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Citations

Dec 28, 2018·Brain Pathology·Simone BaiardiPiero Parchi
Nov 3, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Alicia Gonzalez-MartinezJosé Vivancos
Nov 2, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Sigrid KlotzEllen Gelpi

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