Brainstem and spinal cord MRI identifies altered sensorimotor pathways post-stroke.

Nature Communications
Haleh KarbasforoushanJulius P A Dewald

Abstract

Damage to the corticospinal tract is widely studied following unilateral subcortical stroke, whereas less is known about changes to other sensorimotor pathways. This may be due to the fact that many studies investigated morphological changes in the brain, where the majority of descending and ascending brain pathways are overlapping, and did not investigate the brainstem where they separate. Moreover, these pathways continue passing through separate regions in the spinal cord. Here, using a high-resolution structural MRI of both the brainstem and the cervical spinal cord, we were able to identify a number of microstructurally altered pathways, in addition to the corticospinal tract, post stroke. Moreover, decreases in ipsi-lesional corticospinal tract integrity and increases in contra-lesional medial reticulospinal tract integrity were correlated with motor impairment severity in individuals with stroke.

Associated Clinical Trials

References

Apr 1, 1996·Stroke; a Journal of Cerebral Circulation·J S Kim, S Choi-Kwon
Dec 31, 1997·Stroke; a Journal of Cerebral Circulation·S C CramerB R Rosen
Jan 28, 1998·Stroke; a Journal of Cerebral Circulation·Y CaoK M Welch
Mar 4, 2000·Stroke; a Journal of Cerebral Circulation·R S MarshallR L DeLaPaz
Mar 4, 2000·Stroke; a Journal of Cerebral Circulation·S C CramerB R Rosen
Jul 15, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·D J WerringA J Thompson
Mar 26, 2002·Brain : a Journal of Neurology·James R CareyKamil Ugurbil
Oct 23, 2002·Human Brain Mapping·Stephen M Smith
Aug 26, 2003·Brain : a Journal of Neurology·N S WardR S J Frackowiak
Oct 31, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·T E J BehrensS M Smith
Oct 27, 2004·NeuroImage·Stephen M SmithPaul M Matthews
Jan 18, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·G ThomallaJ Röther
Aug 24, 2005·Nature Neuroscience·Sara L BengtssonFredrik Ullén
Jan 20, 2006·Brain : a Journal of Neurology·Nick S WardRichard S J Frackowiak
Apr 21, 2006·NeuroImage·Stephen M SmithTimothy E J Behrens
Jan 11, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·M MøllerL Østergaard
Aug 10, 2007·Neurorehabilitation and Neural Repair·Sarah F TysonRaymond C Tallis
Sep 18, 2007·Brain : a Journal of Neurology·Marilyn F KrausDeborah M Little
Mar 15, 2008·AJNR. American Journal of Neuroradiology·P MukherjeeR G Henry
Oct 2, 2009·Neurorehabilitation and Neural Repair·Sean P DukelowStephen H Scott
Oct 13, 2009·Nature Neuroscience·Jan ScholzHeidi Johansen-Berg
Sep 8, 2010·Neuropsychologia·Martin LövdénUlman Lindenberger
Sep 8, 2010·Molecular Psychiatry·V HeiseC E Mackay
Jul 31, 2012·Neurology·Theodor RüberRobert Lindenberg
Jan 17, 2014·NeuroImage. Clinical·Yohei TakenobuHidenao Fukuyama
May 2, 2014·NeuroImage·Benjamin De LeenerJulien Cohen-Adad
Apr 19, 2015·Progress in Brain Research·Stuart N BakerDemetris S Soteropoulos
Oct 11, 2016·NeuroImage·Benjamin De LeenerJulien Cohen-Adad
Feb 20, 2018·The Journal of Physiology·Jacob G McPhersonJulius P A Dewald
May 26, 2018·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Boubker ZaaimiStuart N Baker
Oct 17, 2018·NeuroImage·Tanguy DuvalJulien Cohen-Adad

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Citations

Dec 5, 2019·Journal of Neural Engineering·Altamash HassanLaura Miller McPherson
Mar 8, 2020·The Journal of Physiology·Kevin B WilkinsJulius P A Dewald
May 27, 2020·Neurorehabilitation and Neural Repair·Supriyo ChoudhuryStuart N Baker
Nov 16, 2019·Experimental Brain Research·Keith D RunnallsWinston D Byblow
Jan 30, 2020·Frontiers in Systems Neuroscience·Nirvik SinhaYuan Yang
Jan 5, 2021·Experimental Brain Research·Marziye RahimiClaire F Honeycutt
Oct 3, 2020·Experimental Neurology·Frederique WietersMarkus Aswendt
Mar 5, 2021·Topics in Stroke Rehabilitation·Alexander J BarryElliot Roth
Mar 6, 2021·Journal of Neuroscience Research·Brice T Cleland, Sangeetha Madhavan
Jun 17, 2021·Scientific Reports·Andrea ZonninoFabrizio Sergi
Jun 27, 2021·Proceedings of the National Academy of Sciences of the United States of America·Amy N AdkinsWendy M Murray
Aug 18, 2021·Nature Protocols·Julien Cohen-AdadJunqian Xu

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Methods Mentioned

BETA
imaging techniques

Software Mentioned

FMRIB Software Library
FMRIB FDT
FSL
FNIRT
McFlirt Motion Correction
DTIFIT
FMRIB Brain Extraction Tool
SPM12
MATLAB
Eddy Current

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