Brainstem astroblastoma with MN1 translocation

Neuropathology : Official Journal of the Japanese Society of Neuropathology
Sun Ah ShinSung-Hye Park

Abstract

Astroblastoma is a rare glial neoplasm that occurs mostly in the cerebral hemisphere of children, adolescents and young adults. Although astroblastic perivascular pseudorosettes are unique histopathology of this neoplasm, diagnosis is usually challenging. Recently, it was discovered that the meningioma 1 gene (MN1)-altered pediatric central nervous system high-grade neuroepithelial tumors are actually astroblastomas. This case report presents a rare brainstem astroblastoma, with an unusual immunoprofile: negative for glial fibrillary acidic protein and oligodendrocyte transcription factor 2, but with a robust expression of pancytokeratin and epithelial membrane antigen. The diagnosis was confirmed based on the detection of MN1 rearrangement in a fluorescence in situ hybridization study, in addition to typical histopathology. Here we discuss the diagnostic pitfalls and unclear grading system along with a literature review.

References

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Sep 16, 2004·Pediatric Neurosurgery·Bong-Soo KimGeorge Jallo
Jan 18, 2005·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Ramon NavarroTadanori Tomita
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Citations

May 22, 2019·Brain Tumor Pathology·Radhika MhatreVani Santosh
Sep 23, 2020·Pediatric Blood & Cancer·Lorena V BaroniDaniel Alderete
May 23, 2019·Frontiers in Genetics·Giuseppe PetruzzellisEvelina Miele
Mar 13, 2019·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Özlem YapıcıerTürker Kılıç
Jul 17, 2021·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Ramazan SariIlhan Elmaci
Nov 25, 2021·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Ryo KurokawaToshio Moritani

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