Brainstem auditory outcomes and correlation with neurodevelopment after perinatal asphyxia

Pediatric Neurology
Ze D JiangAndrew R Wilkinson

Abstract

We used brainstem auditory-evoked responses and neurodevelopmental assessment to detect abnormalities and correlations between such responses and neurodevelopmental outcomes in 78 children (aged 4-12 years) who survived perinatal asphyxia. Twenty children had brainstem auditory-evoked response abnormalities, including increased threshold, reduced wave V amplitude, decreased V/I amplitude ratio, and prolonged I-V interval. Thirty-seven exhibited neurodevelopmental deficits, including cerebral palsy and developmental delay. The remaining 41 exhibited no deficits. Brainstem auditory-evoked response abnormalities were evident in 15 of 37 (40.5%) children with neurodevelopmental deficits, but in only 5 of 41 (12.2%) with no deficits, which differed significantly (chi(2) = 8.2, P < 0.05). The sensitivity, specificity, positive predictive value, and false-negative rate of brainstem auditory-evoked responses to reflect neurodevelopmental outcomes were 40.5%, 87.8%, 75.0%, and 59.5%, respectively. These findings suggest that in children who survive perinatal asphyxia, brainstem auditory impairment occurs more frequently in those with versus those without neurodevelopmental deficits. Brainstem auditory-evoked responses display a moderate...Continue Reading

References

Feb 1, 1988·Developmental Medicine and Child Neurology·A MajnemerP Riley
Jun 1, 1983·Archives of Neurology·J E StockardB F Westmoreland
Jun 1, 1980·International Journal of Pediatric Otorhinolaryngology·P KilenyC Robertson
May 24, 2005·International Journal of Pediatric Otorhinolaryngology·Masaki SanoKazuo Kodama

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Citations

Feb 19, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Mia K JulkunenOuti Tammela
Feb 26, 2013·International Journal of Pediatric Otorhinolaryngology·Yüksel OlgunSemih Sütay
Dec 15, 2010·Early Human Development·Jaana A LeipäläVineta Fellman
May 18, 2010·Pediatric Neurology·Regina TrollmannDieter Wenzel
Mar 25, 2010·Child Development·Janet A DiPietroJoseph P Pillion
Nov 22, 2016·Neural Plasticity·Ana Alves-PintoRenée Lampe
Nov 1, 2011·Developmental Disabilities Research Reviews·Emanuel Tirosh, Michael Jaffe

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